Astrocytes repress the neuronal expression of GLAST and GLT glutamate transporters in cultured hippocampal neurons from embryonic rats. Neurochem Int. 2004; 45 :1113–1123.Plachez C, Martin A, Guiramand J, Recasens M. 2004. Astrocytes repress the neuronal expression of GLAST and GLT glutamate ...
Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes 喜欢 0 阅读量: 14 摘要: Sept2 is a member of the septin family of GTPases. Septins form filaments in a GTP-form dependent manner, and are involved in cytokinesis from yeast to mammals; however, ...
The protein is distributed in both grey matter astrocytes and radial glial cells, and in white matter where it is localized to oligodendrocytes. We have not excluded the possibility that the protein might also be expressed in white matter astrocytes because of the extent of staining in the white...
GLAST, a glutamate–aspartate transporter expressed by astrocytes with a role in glutamate uptake, is highly expressed on the plasma membrane of glioblastoma (GBM) cells, and its expression significantly correlates with shortened patient survival. Here, it was demonstrated that inhibition of GLAST ...
Important Notice: As a transmembrane protein, GLAST immunostaining displays punctate/reticular-like structures and is not suitable for outlining the shape of astrocytes in vivo, especially in adult animals. Immunogen: The intracellular fragment of rat GLAST fused to GST. Purification: Affinity purificat...
In rodent, GLAST is expressed on astrocytes mainly in cerebellum, but also in forebrain regions including cerebral cortex and hippocampus (Torres and Amara, 2007). Postmortem studies revealed no changes in expression of glutamate transporter GLAST in the striatum (McCullumsmith and Meador-Woodruff, ...
Astrocytes are responsible for clearance of extracellular glutamate, primarily through glial-specific glutamate transporter-1 and the Na+-dependent glutama... YP Liu,CS Yang,MC Chen,... - 《Journal of Neurochemistry》 被引量: 53发表: 2010年 Glutamate signaling in bone Activation of ionotropic glu...
The findings documented that GLAST is expressed by Bergmann glia and by astrocytes throughout the CNS. The glial localization of GLAST mRNA was verified unequivocally by double-labeling with an astrocytic marker protein. Additionally, GLAST mRNA reactivity and GLAST immunoreactivity were found in ...
Here, using CreER T2 –LoxP recombination technology, we generated inducible and astrocyte﹕pecific GDNF conditional knockout (cKO), that is, GLAST〨DNF/ cKO mice to investigate the effect of reactive astrocytes (RAs)ヾerived GDNF on neuronal death, brain damage, oxidative stress and motor ...
Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes. Glia 2003; 43: 175-84.A.S. Hazell, P. Pannunzio, K.V. Rama Rao, D.V. Pow, A. Rambaldi, Thiamine deficiency results in downregulation of the GLAST gluta- mate transporter in cultured ...