CNSNeurons or nerve cellsNeuroglial Cells: Astrocytes Oligodendrocytes Microglia Ependyma PNSGanglion neuronsSchwann cells Satellite cells The nervous system is a very complex network of (a) neurons, the parenchymal cells that transmit and conduct impulses, and (b) various types of neuroglial cell ...
However, the extent of Schwann cell interaction with CNS axons is greatly influenced by the presence of astrocytes which redefine the CNS-PNS (peripheral nervous system) boundary in a lesioned CNS, thereby preventing invasion of Schwann cells. The molecular basis for this restrictive effect of ...
Additionally, in the CNS, astrocytes produce S1P through activity of Sphingosine Kinase 1 (SphK1) and alterations in this pathway are involved in the pathogenesis of inflammatory CNS conditions, such as Multiple Sclerosis49. We have previously noted alterations in splenic B-lymphocyte populations in ...
Immunoblots of cytoskeletal preparations of bovine splenic nerve or rat sciatic nerve showed that the antigen from peripheral nerves comigrated at 50 kDa with antigen from bovine or rat spinal cord or cultured rat astrocytes. The CNS and PNS 50-kDa proteins from bovine tissues were subjected to ...
In disorders characterized by mechanical CNS damage, such as brain injury and neurodegenerative disorders, it seems logical that leakage of astrocyte-derived EVs through the BBB could be measured in peripheral blood. However, the pathophysiological mechanism and thus the clinical relevance is yet to ...
Macroglia (astrocytes and oligodendrocytes) are required for normal development and function of the central nervous system, yet many questions remain about their emergence during the development of the brain and spinal cord. Here we used single-cell/sing
In previous studies, we have demonstrated that anti-EBA exclusively recognizes barrier-competent microvessels in the rat central and peripheral nervous system (CNS and PNS) and is negative in endothelial cells of peripheral tissues such as the heart and kidney. The antigen is also absent in brain...
Brain Sci. 2019, 9, 83 10 of 11 Abbreviations AC ACfp BBB BM CBF CKC CL CNS DBC DBE EC FIB/SEM LOAD NVU Pc PYR T2DM TEM TJ/AJ RBC SGLT2i astrocyte astrocyte foot processes blood-brain barrier basement membrane cerebral blood flow control: lean non-diabetic female heterozygous +/-C57B...