Peptides derived from an internal image carrying anti-idiotypic antibody are hypothesized to facilitate the perpetuation of antigen specific T cell memory through similarity in peptide-MHC binding as that of the antigenic peptide. In the present work, the existence of such peptidomimics of the ...
把表位长度确定好之后,重新将G12D、G12V、G12R、G13D重新进行IEDB的MHC-I Binding Prediction。 结果显示,四条突变序列相对于野生型序列都可以找到大量的突变位点特异性的且具备一定较高亲和力的HLA-I型别,即在标红的HLA-I型别患者中,有可能设计出肿瘤特异性抗原。
The binding site on MHC-Class-I for Ly49 inhibitory receptors is distinct from that for TCRs. The loss of MHC-I expression on tumor cells ("missing self") abrogates inhibitory signals, resulting in NK activation. Global inhibition of the NK inhibitory receptor interactions in vivo by a pan...
The binding interface between the light and heavy chains of the MHC-1 has been probed by X-ray crystallography, the data revealing a large (1348 Å2) interface involving hydrogen bonding, salt bridges, and hydrophobic interactions that stabilize the complex [3, 32, 38]. The larger number ...
This technique is used to study protein-protein interactions within cells and involves the reconstitution of a visible fluorophore from split fluorescent molecules expressed as fusion proteins on two distinct putative protein binding partners19–21. BiFC has enabled us and others to identify locations ...
receptor binding protein binding beta-2-microglobulin binding peptide binding peptide antigen binding T cell receptor binding poly(A) RNA binding TAP binding protein heterodimerization activity major histocompatibility complex protein 参与通路 positive regulation of T cell mediated cytoto...
receptor binding protein binding beta-2-microglobulin binding peptide binding peptide antigen binding T cell receptor binding poly(A) RNA binding TAP binding protein heterodimerization activity major histocompatibility complex protein 参与通路 positive regulation of T cell mediated...
ABCATP——bindingcassettesuperfamily转运蛋白超家族 PLCPeptide——loadingcomplex肽段转运复合体 链霉菌抗生物素蛋白一过氧 S-PStreptavidin—Peroxidase 化物酶 ’ 学位论文独创性说明 本人所呈交的学位论文是在我导师的指导下进行的研究工作及取得的成果。据 ...
The binding of CTL epitopes to MHC class I molecules is linear, anchor- ing at residues 2 and 9; hence the interface between ligand and CTL can be determined computationally [29]. Validation of such computational applications can be done by comparing their predictions with suit- able ...
Identification of a novel immunogenic HLA-A*0201-binding epitope of HER-2/neu with potent antitumor properties. HER-2/neu oncoprotein is overexpressed in a variety of human tumors and is associated with aggressive disease. Immunogenic HER-2/neu CTL epitopes have been... AD Gritzapis,IF Voutsas...