A newly synthesized classical MHC class II molecule, HLA-DP, -DQ, or -DR in humans, is transported from theendoplasmic reticulumto the MHC class II compartment (MIIC) of endosomal compartments by binding to a protein called theinvariant chain(Ii), which blocks the peptide-binding groove of ...
More than 90% of the major histocompatibility complex (MHC) class II molecules on antigenpresenting cells (APC) have in their binding site a peptide derived from an extracellular protein ingested by the APC or from a protein of the APC itself. These self-peptides can be eluted from affinity...
未成熟的MHC-I型分子通过肽装载复合物(peptide loading complex,由Tapsin、Erp57和钙网蛋白(Crt)组成)保持稳定。负载抗原肽后成为成熟的MHC I型复合物,通过高尔基体运送至细胞表面。MHC-II类肽路径(蓝色):外源性抗原通过内涵体途径被摄取,未成熟的MHC-II蛋白复合物通过固定链(Invariant chain(li))保持稳定,并通过...
货号15-5321-82 CNY2,771.00 查看价格 数量 有货 批量或定制请求 性能保障 说明书 实验方案 技术支持 Application Created with Sketch. 图:1/81 MHC Class II (I-A/I-E) Antibody (15-5321-82) in Flow Cell death discovery 2021 -Fig. 1 Isolation and identification of Wip1 -/- MSCs from murine...
This protein is an MHC class I alloantigen, which is involved in antigen presentation to T cells expressing CD3/TCR and CD8.HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-pe...
3、tor X, RFX, 与X1盒结合)、 核因子Y(nuclear factor Y, NFY, 与Y盒结合)、 cAMP反应性结合蛋白(cAMP responsive binding protein, CREB, 与X2盒结合)等几乎表达于所有细胞。MHCII基因反式作用子(class II transactivator, CIITA)在研究裸淋巴细胞综合征时被分离, 发现其通过影响MHCII的转录水平, 从而调...
The mouse major histocompatibility complex class II (MHC- II /H-2 II BJ-M3381 规格:96T/48T 性状:液体 存储:4℃保存6个月 运输方式:快递发货 检测标本:血清,血浆,尿液,胸腹水,脑脊液,细胞培养上清,组织匀浆等 自备材料: 1)蒸馏水。 2)加样器:5ul、10ul、50ul、100ul、200ul、500ul、1000ul。
Additional information How to cite this article: Wieczorek, M. et al. MHC class II complexes sample intermediate states along the peptide exchange pathway. Nat. Commun. 7, 13224 doi: 10.1038/ncomms13224 (2016).Accession codes Accessions Protein Data Bank 4X5W 4X5X References McFarland, B....
(Ii). A protein that binds to newly synthesized MHC class II molecules and promotes their egress from the endoplasmic reticulum. It blocks the peptide-binding site on nascent MHC class II molecules and targets Ii–MHC class II complexes to late endosomal and lysosomal antigen-processing compartment...
class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lympho...