MHCfovea integrates a supervised prediction module and an unsupervised summarization module to connect important residues to binding motifs (Fig.1). The predictor in the prediction module is constructed of an ensemble model based on convolutional neural networks (CNN) (Supplementary Fig.1) embedded wit...
ACME: pan-specific peptide–MHC class Ibinding prediction through attention-based deep neural networks .Bioinformatics,Volume 35, Issue 23, 1 December 2019, Pages 4946–4954 https://academic.oup.com/bioinformatics/article/35/23/4946/5497763 转载或合作请联系邮箱 intbioinfo@163.com ...
MHCflurry implements class I peptide/MHC binding affinity prediction. The current version provides pan-MHC I predictors supporting any MHC allele of known sequence. MHCflurry runs on Python 3.9+ using thetensorflowneural network library. It exposescommand-lineandPython libraryinterfaces. ...
Competition-based cellular peptide binding assay for HLA class I 10.1002/0471142735.im1812s61 Google Scholar Kim et al., 2014 Y. Kim, J. Sidney, S. Buus, A. Sette, M. Nielsen, B. Peters Dataset size and composition impact the reliability of performance benchmarks for peptide-MHC binding ...
近日，来自瑞士University of Lausanne的Alexandre Harari和David Gfeller研究组在Immunity上发表题为Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes的文章，就上述问题进行了深入探讨。人类的MHC-II也被称之为HLA-II，包含有三个可以直接给CD4+T细胞递呈抗原的...
1 TCR-HEK293 cells (pool) were stained with PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Protein(Fig B)and negative control protein respectively (Fig. A), and competitor-M represented competitor protein (Fig. C). PE signal was ...
The MHC Motif Atlas:a database of MHC binding specificities and ligands 作者:Daniel M.Tadros, Simon Eggenschwiler, Julien Racle, David Gfeller 作者单位:瑞士洛桑大学路德维希癌症研究所(LICR)和瑞士生物信息研究所(SIB) Nucleic Acids Research, 2023, Vol. 51, Database issue Published online 1 Novembe...
On the cover: The peptide binding groove of the reptile peptide–MHC class I–β2 microglobulin is mainly composed of the main anchor amino acids that form a hydrogen bond and salt bridge network that interacts with...
首先,作者开发了全新的肿瘤抗原预测算法hmMHC(a hidden Markov model-based MHC binding predictor),筛选和预测出mITGB1(integrin-β1)的N710Y突变体很可能是T3肉瘤细胞(T3 sarcoma cells)的MHC II型肿瘤抗原。接下来,作者通过ELISPOT(Enzyme-linked immune absorbent spot )等方法,证实了这一推测。 接下来,作者开...
Supplementary Figure 1 Binding capacity of DNA-barcoded MHC multimers and recovery of antigen specificity (a, b) Fluorescent-based determination of the binding capacity of DNA-barcoded MHC multimers (+barcode) compared to fluorescent labeled MHC multimers (-barcode). DNA-barcoded MHC multimer reage...