This protein is an MHC class I alloantigen, which is involved in antigen presentation to T cells expressing CD3/TCR and CD8. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performa...
-beta transplantation antigen protein; H2DD; H2K1; H2KD; MHC class I antigen; MHC class I H-2Dp; MHC class I H2 antigen; MHC class I H2-K-b-alpha-2 cell surface glycoprotein; MHC class I heavy chain H2-K; MHC H2-D-q alpha-chain; MHC H2-K transplantation antigen...
Pathways for loading exogenous protein-derived peptides on MHC class I are thought to be present mainly in monocyte-lineage cells and to involve phagocytosis- or macropinocytosis-mediated antigenic leakage into either cytosol or extracellular milieu to give peptide access to MHC class I. We show tha...
A.: Prediction of MHC class I binding - Donnes, Elofsson - 2002 () Citation Context ...ntly impractical [9]. Therefore, there has been a growing interest in computational methods that predict HLA protein-peptide binding. M...
The MHC class I molecule is a three-domain protein that forms a peptide-binding groove such that antiparallel β sheets form the floor of the groove and α helices form the sides of the groove. From: The Enzymes, 2017 About this pageAdd to MendeleySet alert ...
Direct Binding of the MHC Class I Molecule H-2Ld to CD8: Interaction with the Amino Terminus of a Mature Cell Surface Protein 来自 Semantic Scholar 喜欢 0 阅读量: 28 作者:MT Jelonek,BJ Classon,PJ Hudson,DH Margulies 摘要: MHC class I molecules (MHC-I) display peptides from the ...
MHC class I molecules adopt a peptide-receptive conformation that is highly unstable until the peptide binds. To help stabilize them, MHC class I molecules are recruited into a multimericprotein complextermed the peptide-loading complex, in which stable MHC class I–peptide complexes are preferentiall...
(MHC) class I chain-related protein A (MICA) and MHC class I chain-related protein B (MICB) are polymorphic proteins that are induced upon stress, damage or transformation of cells which act as a 'kill me' signal through the natural-killer group 2, member D receptor expressed on ...
binding cleft, a highly polymorphic region, contributing to the diversity of MHC-I-binding motifs9. There are >13,000 MHC-I alleles on a four-digit level (e.g., A*02:01) recorded in the IPD-IMGT/HLA database10, representing a particular protein sequence. Thus, it is difficult to ...
The major histocompatibility complex (MHC) class I molecules are ubiquitous molecules involved in the . We show here, using a number of different, independent approaches, that these proteins are an essential component of the receptor involved in sporozoite invasion. Monoclonal antibodies (mAbs) reactiv...