Disclosed is a non-human animal comprising at an endogenous Major Histocompatibility Complex II (MHC II) gene locus a nucleotide sequence encoding a chimeric human/non-human MHC II polypeptide and/or comprising at an endogenous MHC II gene locus a nucleotide sequence encoding a chimeric human/non...
S. Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells. Eur. J. Immunol. 26, 2456–2460 (1996). CAS PubMed Google Scholar ...
(1)经典MHC基因经典MHCI类相关基因HLA-A、B、C、经典MHCII类相关基因HLA-DP、DQ、DR(2)免疫功能相关基因编码补体成分的基因C2、C4A、C4B、Bf(III类区),抗原加工递呈相关基因LMP、TAP、HLA-DM、HLA-DO(II类区),非经典I类基因HLA-E、F、G(I类区),炎症相关基因TNF、HSP70(III类区),基因座位genelocus,指...
For simplicity, when referring to the complete MHC haplotype, e.g., the b haplotype, we use MHCb/b, when referring to the MHCII locus, MHCIIb/b, and for the expressed protein hereof, I-Ab/b. To explore the hypothesis that the first autoreactive clone broke tolerance among WT clones...
As inducible T cell costimulator (ICOS) is expressed preferentially on both T cells and ILC2s, we inserted a floxed DTx receptor (DTR) gene into the Icos locus (resulting in a null allele) enabling the CD4-cre-mediated excision of the DTR gene from T cells but its retention in ILC2s ...
Class I and Class II MHC TheMHC class Imolecule is aheterodimercomposed of a heavy chain of about 350amino acids, which is encoded within the MHC locus, and a light chain of about 100 amino acids, β2microglobulin, which is encoded elsewhere. The structure of an MHC class I molecule is...
Major histocompatibility complex (MHC) genes play important role in host–parasite interactions and parasites are crucial factors influencing the population dynamics of hosts. We described the structure and diversity of exon 2 of the MHC class IIDQAgene in three species of voles (Arvicolinae) exhibi...
MHC分子/抗原H-2分子HLA分子 移植抗原 组织相容性抗原基因MHC、H-2、HLA分子第六张,PPT共五十一页,创作于2022年6月医学免疫学上海第二医科大学免疫教研室二、MHC复合体结构MHC I、II、III类基因及多种免疫功能相关gene,各含多个gene locus(座位)、亚区(subregions)* 多基因性(polygenic)第七张,PPT共五十一页...
Loss of MHC II expression in immune-privileged (IP) DLBCL subsets occurs through deletions of the MHC II locus, while chromosomal translocations resulting in CIITA gene fusions in Hodgkin lymphoma cell lines lead to downregulation of MHC II molecules on the cell surface.22 However, no similar com...
M. Regulation of MHC class II gene expression by the class II transactivator. Nature Rev. Immunol. 5, 793–806 (2005). Article CAS Google Scholar Smith, M. A. et al. Positive regulatory domain I (PRDM1) and IRF8/Pu.1 counter-regulate MHC class II transactivator (CIITA) expression ...