目的 探究调控恶性黑素瘤转移的lncRNA-TF-mRNA分子网络,寻找预后相关标志物.方法 下载TCGA数据库中皮肤恶性黑素瘤样本转录组数据,筛选在转移样本中高表达的lncRNA,TF与mRNA,进行相关性分析及预测,绘制互作网络.最后通过多因素COX回归,构建预后模型,寻找预后标志物.结果 共鉴定出2 719个差异基因,其中1 920个在转移...
(transcription factors,TF)-miRNAmRNA调控机制和长链非编码RNA(long non-coding RNA,lncRNA)-miRNA-mRNA调控机制.方法:整合了胰腺癌组织和正常组织的基因芯片表达数据来识别胰腺癌中差异表达的mRNA,miRNA与lncRNAs.其次结合StarBas数据库中miRNA-mRNA互相作用的实验数据——基于紫外交联免疫沉淀结合高通量测序(cross...
The hubs showed significant connectivity with the modules.Through this study we were able to gain insights into the underlying lncRNA-miRNA-mRNA-TF network. From a high throughput dataset we have isolated a handful of probable targets that may be utilized for studying the mechanisms of DCM ...