we present a rapid and cost-effective lipid nanoparticle(LNP)encapsulated-mRNA platform for in vivo delivery of SARS-CoV-2 neutralization antibodies.Two mRNAs encoding the light and heavy chains of a potent SARS-CoV-2 neutralizing antibody HB27,which is currently being evaluated in clinical trials...
et al. Branched-tail lipid nanoparticles potently deliver mRNA in vivo due to enhanced ionization at endosomal pH. Small 15, 1805097 (2019). Google Scholar Hajj, K. A. et al. A potent branched-tail lipid nanoparticle enables multiplexed mRNA delivery and gene editing in vivo. Nano Lett. ...
Kim, H., Zenhausern, R., Gentry, K.et al.Lipid nanoparticle-mediated mRNA delivery to CD34+cells in rhesus monkeys.Nat Biotechnol(2024). https://doi.org/10.1038/s41587-024-02470-2 Download citation Received15 April 2024 Accepted15 October 2024 ...
同时,mRNA是单链分子,非常脆弱,容易被核酸酶降解或被免疫细胞吞噬,难以递送至细胞内编码蛋白,需要特殊的修饰或包裹递送系统才能实现mRNA药物的胞内表达。因此,递送技术是mRNA治疗成功与否的关键。 01 LNP组成 脂质纳米颗粒(Lipid Nanoparticle,LNP) 是目前主流的载体递送方式,现阶段主要的mRNA疫苗都使用的是此项技术...
Fig. 1: Timeline of some key milestones for mRNA and lipid nanoparticle development. COVID-19, coronavirus disease 2019; EMA, European Medicines Agency; FDA, United States Food and Drug Administration; LNP, lipid nanoparticle251,252,253.
The FDA-approved and other clinically advanced mRNA vaccines and therapeutics rely on a lipid nanoparticle-based delivery vehicle to protect the mRNA cargo and deliver it to the cytosol of target cells [8,9]. Fortunately, numerous lipid nanoparticles have been discovered that potently deliver mRNA ...
The mRNA platform has become an attractive platform for antigen presentation. The delivery of mRNA cancer vaccines via lipid nanoparticles (LNPs) enables intracellular delivery and controlled release of the payload, offering improved vaccine efficacy. However, mRNA vaccines presenting human T cell ...
The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tes
Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys 脂质纳米颗粒介导的mRNA递送至恒河猴CD34+细胞 相关领域 归巢(生物学) 造血 离体 体内 骨髓 祖细胞 川地34 免疫学 细胞因子 细胞生物学 化学 生物 干细胞 生态学 生物技术 ...
To elicit optimal immune responses, messenger RNA vaccines require intracellular delivery of the mRNA and the careful use of adjuvants. Here we report a multiply adjuvanted mRNA vaccine consisting of lipid nanoparticles encapsulating an mRNA-encoded anti