Herein, we present a rapid and cost-effective lipid nanoparticle (LNP) encapsulated-mRNA platform for in vivo delivery of SARS-CoV-2 neutralization antibodies. Two mRNAs encoding the light and heavy chains of a potent SARS-CoV-2 neutralizing antibody HB27, which is currently being evaluated in ...
The approval of messenger RNA (mRNA)-based COVID-19 vaccines has revolutionized the field of vaccine development and opened up a realm of possibilities for developing mRNA medicines targeting a wide range of diseases1. Inhaled delivery of mRNA has emerged as a promising approach for treating vario...
同时,mRNA是单链分子,非常脆弱,容易被核酸酶降解或被免疫细胞吞噬,难以递送至细胞内编码蛋白,需要特殊的修饰或包裹递送系统才能实现mRNA药物的胞内表达。因此,递送技术是mRNA治疗成功与否的关键。 01 LNP组成 脂质纳米颗粒(Lipid Nanoparticle,LNP) 是目前主流的载体递送方式,现阶段主要的mRNA疫苗都使用的是此项技术...
In conclusion, the lipid nanoparticle formulation presented here is a promising vector for mRNA vaccine delivery, one that is capable of inducing a strong cytotoxic T cell response. Further optimization, including the incorporation of different adjuvants, will likely enhance the potency of the vaccine...
Precision NanoSystems is a global leader in technologies, solutions and services for the development of lipid nanoparticle delivery of genomic medicines, including mRNA vaccines and therapeutics.
By simultaneously varying lipid ratios and structures, we developed an optimized formulation which increased the potency of erythropoietin-mRNA-loaded C12-200 lipid nanoparticles 7-fold relative to formul... 展开 关键词: in vivo nucleic acid design of experiment mRNA Lipid nanoparticle ...
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A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP product stability and thereby ease the temperature condi...
Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy. Nano Lett. 2017, 17, 1326–1335. [CrossRef] [PubMed] 24. Guevara, M.; Persano, F.; Persano, S. Advances in lipid nanoparticles for mRNA-based cancer immunotherapy. Front. Chem. 2020, 8, 589959. [CrossRef] 25. ...
Lipid nanoparticles can be classified according to their structure and drug-delivery mechanism: solid lipid nanoparticles, nanostructured lipid carriers, lipid nanocapsules, lipid–drug conjugates, polymeric lipid-hybrid nanoparticle lipids, etc. [67]. Different types of LNPs have different preparation metho...