which severely restricts their availability. Herein, we develop a lyophilization technique to prepare SARS-CoV-2 mRNA-lipid nanoparticle vaccines with long-term thermostability. The physiochemical properties
This lipid nanoparticle lyophilized composition is free from nucleic acids and contains an ionic lipid, sterol, a PEG-lipid, an acidic buffer solution component having a buffering action at a pH of 1-6, and a cryoprotectant. The weight ratio of the cryoprotectant and all the lipids is 10:1...
Lyophilization of nanoparticle formulations is a common process to increase colloidal stability and shelf life used in academic reserach and industrial settings. A recent relevant example is the challenge in the transportation and storage of the COVID vaccine, which is an mRNA complexed with lipid ...
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine 2022, Molecular Therapy Show abstract Preservation of biomaterials and cells by freeze-drying: Change of paradigm 2021, Journal of Controlled Release Show abstract Parenteral protein formulations:...
Ampati, K. Jayaveera, Enhanced intestinal absorption and bioavailability of raloxifene hydrochloride via lyophilized solid lipid nanoparticles, Adv. Powder Technol. 24 (2013) 393- 402.Burra M, Raju Jukanti R, Janga KY, Sunkavalli S, Velpula A, Ampati S, et al. Enhanced intestinal absorption...