However, most current mRNA delivery platforms need to be stored at 20掳C or 70掳C due to their poor stability, which severely restricts their availability. Herein, we develop a lyophilization technique to prepare SARS-CoV-2 mRNA-lipid nanoparticle vaccines with long-term thermostability. The ...
Lyophilization of nanoparticle formulations is a common process to increase colloidal stability and shelf life used in academic reserach and industrial settings. A recent relevant example is the challenge in the transportation and storage of the COVID vaccine, which is an mRNA complexed with lipid ...
which severely restricts their availability. Herein, we develop a lyophilization technique to prepare SARS-CoV-2 mRNA-lipid nanoparticle vaccines with long-term thermostability. The physiochemical properties
This lipid nanoparticle lyophilized composition is free from nucleic acids and contains an ionic lipid, sterol, a PEG-lipid, an acidic buffer solution component having a buffering action at a pH of 1-6, and a cryoprotectant. The weight ratio of the cryoprotectant and all the lipids is 10:1...
Enhanced intestinal absorption and bioavailability of raloxifene hydrochloride via lyophilized solid lipid nanoparticles. Adv Powder Technol 2013;24:393-402.Madhu B, Raju J, Karthik Yadav J, et al. (2013). Enhanced intestinal absorption and bioavailability of raloxifene hydrochloride via lyophilized solid...
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2. Cell Discov. 2023, 9, 9. [Google Scholar] [CrossRef] [PubMed] Suzuki, Y.; Miyazaki, T.; Muto, H.; Kubara, K.; Mukai, Y.; Watari, R.; Sato, S.; Kondo, K.; Tsukumo,...