Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow ce
mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, ...
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We
Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxi
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells. J Control Release. 2022;347:521–532. doi:10.1016/j.jconrel.2022.05.020 (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar...
Currently, lipid nanoparticles (LNPs) are one of the most advanced delivery platforms being developed for systemic RNAi delivery [2]. LNPs contain ionizable cationic lipids that bind nucleic acids via electrostatic interactions, resulting in efficient siRNA encapsulation and a uniform LNP population of...
In this review, we explore the potential applications of lipid-based nanoparticles (LBNs) in the treatment of AD. Given the intricate nature of AD progression and the current uncertainties in treatment pathways, we propose hypotheses to elucidate the potential mechanisms underlying its development. In...
Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA vaccines are now in clinical use against coronavirus disease 2019 (COVID-19), which marks a milestone for mRNA therapeutics. In this Review, we discuss the design of lipid ...
Hou, X.C., et al., Lipid nanoparticles for mRNA delivery. Nature Reviews Materials, 2021. 6(12): p. 1078-1094. Cheng, X. and R.J. Lee, The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery....
Lipid nanoparticles for the inhalation of mRNARachel Yoon Kyung Chang & Hak-Kim Chan Nature Biomedical Engineering volume 5, pages 949–950 (2021)Cite this article 15k Accesses 46 Altmetric Metrics details Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebulization. This...