In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle–mRNA systems. We then consider key points for the clinical translation of lipid nanoparticle–mRNA formulations, including good ...
mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, ...
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Chemistry of Lipid Nanoparticles for RNA DeliveryPublished as part of the Accounts of Chemical Research special issue “mRNA Therapeutics”.Yulia Eygeris, ∥ Mohit Gupta, ∥ Jeonghwan Kim, and Gaurav Sahay*Cite This: https://doi.org/10.1021/acs.accounts.1c00544 Read OnlineACCESSMetrics & More ...
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis 原文链接:https://doi.org/10.1073/pnas.2116271119 Significance 目前基于mRNA技术的应用主要局限于肝脏疾病,因为缺乏特异性和高效的肝外的体内mRNA递送系统。在这里,我们开发了一个n系列脂质纳米颗粒...
In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle–mRNA systems. We then consider key points for the clinical translation of lipid nanoparticle–mRNA formulations, including good ...
Lipid Nanoparticles From Liposomes tomRNA Vaccine Delivery, a Landscape ofResearch Diversity and AdvancementRumiana Tenchov, Robert Bird, Allison E. Curtze, and Qiongqiong Zhou*Cite This: https://doi.org/10.1021/acsnano.1c04996 Read OnlineACCESSMetrics & More Article Recommendations * sı ...
Lipid nanoparticles (LNPs) represent the most clinically advanced mRNA delivery system with two marketed products, i.e., the COVID-19 mRNA vaccines Comirnaty® and Spikevax® from Pfizer/BioNTech and Moderna, respectively. In general, the LNPs used for mRNA delivery typically include four com...
Lipid nanoparticles for the inhalation of mRNARachel Yoon Kyung Chang & Hak-Kim Chan Nature Biomedical Engineering volume 5, pages 949–950 (2021)Cite this article 15k Accesses 46 Altmetric Metrics details Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebulization. This...
& Dong, Y. Lipid nanoparticles for mRNA delivery. Nat. Rev. Mater. 6, 1078–1094 (2021). Article CAS PubMed PubMed Central Google Scholar Chaudhary, N., Weissman, D. & Whitehead, K. A. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat. Rev. ...