To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA ...
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis 原文链接:https://doi.org/10.1073/pnas.2116271119 Significance 目前基于mRNA技术的应用主要局限于肝脏疾病,因为缺乏特异性和高效的肝外的体内mRNA递送系统。在这里,我们开发了一个n系列脂质纳米颗粒...
题目:Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement 报告人:张子梦 中山大学深圳研究院 时间:2021年9月10日(周五) 20:00 主办:中国微循环学会转化医学专业委员会、医学强基计划、衡山论健组委会...
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We optimized the composition, molar ratios ...
To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA ...
Therefore, mRNA vaccines require a delivery vehicle that not only protects the nucleic acid from degradation but allows the mRNA to get into cells.BioNTech/Pfizer’s and Moderna’s mRNA vaccines both use lipid nanoparticles as mRNA carriers. The impressive speed at which these vaccines could be ...
Lipid nanoparticles for mRNA vaccine deliveryNovel lipid nanoparticles for delivering nucleic acids such as mRNA are provided. Methods of making and using lipid nanoparticles to deliver nucleic acids such as mRNA are also provided.
西奈山lcahn医学院Yizhou Dong-Lipid nanoparticles enabled mRNA therapeutics#西奈山lcahn医学院 #科研云 #科技 #科研 #科普 - 科研云于20230915发布在抖音,已经收获了2.2万个喜欢,来抖音,记录美好生活!
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Lipid nanoparticles for the inhalation of mRNARachel Yoon Kyung Chang & Hak-Kim Chan Nature Biomedical Engineering volume 5, pages 949–950 (2021)Cite this article 15k Accesses 21 Citations 49 Altmetric Metrics details Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebu...