Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced ...
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We optimized the composition, molar ratios ...
Liu Q, Zhang Q (2019) 10 - Nanoparticle systems for nose-to-brain delivery. Brain Target Deliv Syst:219–238 Masserini M (2013) Nanoparticles for Brain Drug Delivery. ISRN Biochem 238428:1–18 Article Google Scholar Naskar S, Sharma S, Kuotsu K (2019) Chitosan-based nanoparticles: an ...
delivery technologies for biopharmaceuticalslipid nanoparticle‐based systems for biomacromolecule therapeutic deliverynovel formulation development for NDEssolid lipid nanoparticles (SLNs) ‐ new class of drug carrierbovine serum albumin (BSA) crystals
To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA ...
lipidnanoparticleconcept TraditionalCarriersLipidNanoparticles 1970ies1950ies19911999/2000 PharmaSolGmbH No.9 No.9 Polymeric nanoparticles polymer (solid) liquid lipid (=oil) o/wemulsion solid lipid SLN 1 st generation solid lipid blend NLC 2
Lipid nanoparticle formulations have undergone remarkable progression in recent few years. To give you just one data point, according to our own internal market analysis, there are now approximately 150 active pipelines that incorporate LNP delivery technologies. What distinguishes this trend is not...
FORMULATION AND EVALUATION OF TROPICAMIDE IN-SITU GELS LOADED SOLID LIPID NANOPARTICLES FOR OCULAR DRUG DELIVERY Preparation,optimization,and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery solid lipid nanoparticleorthogonal designBox-Behnken... Y Ramesh,CB Kothapalli 被引...
By harnessing the benefits of microfluidics for controlling diffusive and advective transport within microfabricated flow cells, microfluidic platforms enable unique capabilities for lipid nanoparticle synthesis with precise and tunable control over nanoparticle properties. Here we present an assessment of the ...
Apart from microspheres, liposomes, and nanoparticle formulations act as promising candidates for prospective drug delivery to the posterior segment of the eye [5]. Due to modifications in their molecular assembly properties, such delivery vehicles can be designed to match the respective demands or ...