Lipid nanoparticles for the inhalation of mRNARachel Yoon Kyung Chang & Hak-Kim Chan Nature Biomedical Engineering volume 5, pages 949–950 (2021)Cite this article 15k Accesses 21 Citations 49 Altmetric Metrics details Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebu...
Here we tested which classes of transfection agents can deliver mRNA to platelets. We found that nanoparticles containing cationic lipids or ionizable cationic lipids can deliver mRNA to platelets with minimal platelet activation. The mRNA remained stable in resting platelets for several hours following...
Leung, A.K.; Tam, Y.Y.; Cullis, P.R. Lipid nanoparticles for short interfering RNA delivery. Adv. Genet. 2014, 88, 71-110. [PubMed]A.K. Leung, Y.Y. Tam, P. R. Cullis, Lipid nanoparticles for short interfering RNA delivery. Adv. Genet., 88 (2014) 71-110....
PRIME PubMedEliminating Intracellular MRSA via Mannosylated Lipid-Coated Calcium Phosphate Nanoparticles. Mol Pharm. 2024 Nov 04; 21(11):5772-5783.MPAbstract Methicillin-resistant Staphylococcus aureus (MRSA) within cells proves exceptionally challenging to eradicate using co...
However, to enable mRNA to fully exploit its effects in vivo, researchers need to develop safer and more effective mRNA delivery systems that improve mRNA stability and enhance the ability of cells to take up and release mRNA. To date, lipid nanoparticles are promising nanodrug carriers for ...
Furthermore, a brighter side of lipid-based nanomaterials as future potential drug delivery systems for breast cancer therapy is discussed. Keywords: drug delivery system; conjugation; targeting; breast cancer; liposomes; exosomes; micelles; safety; efficacy...
Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy. J Control Release. 2022;345:306–13. Article CAS PubMed PubMed Central Google Scholar Zong Y, Lin Y, Wei T, Cheng Q. Lipid Nanoparticle (LNP) Enables mRNA delivery for cancer therapy. Adv ...
Hassett et al., “Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines,” Mol Ther Nucleic Acids (2019). Hiroshi, et al., “Replication of Genetic Information with Self-Encoded Replicase in Liposomes.” ChemBioChem; Oct. 13, 2008; pp. 2403-2410; vol. 9(15)...
The established hyaluronic acid-modified chitosan nanoparticles are recently shown to be effective for the systemic administration of siRNA to tumors [39, 40]. To explore the possibility of using CYP19A1 as a target for sensitizing anti-PD-1 therapy, the effect of nanoparticle-encapsulated CYP19...
Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebulization. It is now clear that messenger RNA (mRNA) encoding the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delivered by lipid nanoparticles (LNPs) triggers the efficient protection of...