p53 is required for nerve growth factor- mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death Differ. 2006;13:2118-28.Zhang J , Yan W , Chen X ( 2006 ) p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA ...
However, to date, no transcription complexes have been shown to control axon outgrowth and regeneration by regulating axon growth genes. Here, we report that the tumor suppressor p53 and its acetyltransferases CBP/p300 form a transcriptional complex that regulates the axonal growth-associated protein ...
Skip to main contentSkip to article Journals & Books Help Search My accountSign in View PDF Download full issue Search ScienceDirect Outline Abstract Results and Discussion Supplementary data Acknowledgements ReferencesShow full outline Cited by (96) Figures (4)...
p53-mediated growth arrest induced by nutlin-3, suggesting that Necdin upregulation could contribute to the bypass of a p53-response in p53 wild type tumors. To support this, we characterized Necdin expression in low malignant potential ovarian cancer (LMP) where p53 mutations rarely occur. ...
p53 Is a Master Regulator of the UPR and Autophagy in SMARCB1-Deficient Tumors To understand cellular reprogramming in Smarcb1-deficient tumors, we conducted transcriptomic analysis of Cre-induced Smarcb1-null liver tumors and LacZ controls identifying significant upregulation of p53 pathways involved in...
Frequent mutations of p53 in human cancers exemplify its crucial role as a tumor suppressor transcription factor, and p21, a transcriptional target of p53, plays a central role in surveillance of cell-cycle checkpoints. Our previous study has shown that
Together, our results put forward the hypothesis that the absence of p53 may determine a higher chemotherapeutic index for 5-aza-dC. 展开 关键词: ONC oncogenes cancer apoptosis tumor suppressor genes tumor viruses molecular oncology cell cycle growth factors growth factor receptors ...
The inability of p53-negative tumor cell lines to support long-term expression of wild-type p53 protein is consistent with the view that p53 is a tumor suppressor gene. 展开 关键词: GROWTH HORMONE LIFE SPAN AGING IMMUNE RESPONSE LONGEVITY IMMUNOLOGICAL THEORY OF AGING DOI: 10.1016/0047-6374(91...
The DNp73 proteins act as trans-repressors of p53 and p73-dependent transcription and exert both anti-apoptotic activity and pro-proliferative activity. DNp73s are frequently up-regulated in a variety of human cancers, including human hepatocellular carcinomas (HCCs). Increased levels of DNp73 prot...
Q Zhan, F Carrier, A.J Fornance Induction of cellular p53 activity by DNA-damaging agents and growth arrest Mol. Cell. Biol., 13 (1993), pp. 4242-4250 View in ScopusGoogle Scholar Cited by (3942) Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor ...