Although positive p53 staining in some Li‐Fraumeni syndrome patients is associated with mutation, in other Li‐Fraumeni‐like families, no mutation has been found despite positive staining in tumour and normal tissues. Whatever the mechanism underlying the stabilisation of the protein, increased ...
we co-stained p53 protein and Clu+cells at 0, 1, 2, or 3 days after 12 Gy using a GFP reporter driven by the Clu promoter (CluGFP) that faithfully recapitulates endogenous Clu expression in the small intestines5. We observed a significant induction of nuclear p53 protein at...
Normally, the p53 protein is switched off during cell stress and uncontrolled division and proliferation [14], while when cell damage cannot be repaired, p53 triggers programmed cell death by activating apoptosis-related genes [15]. Previous studies have shown that p53 is implicated in the ...
Discovered in the 1970s, the tumor suppressor protein p53 (TP53) plays a critical role in the cellular response to various stresses, including DNA damage, hypoxia, nutrition starvation, and oncogene activation [1]. Activation of p53 can lead to survival or death, depending on the levels of s...
1990. The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses. Virology 177 : 419-426. [ PubMed ]Levine,AJ.The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses.Journal of Virology. 1990...
Testino G,,Cornaggia M.p53protein expression in epithelial high-grade dysplasia from the stomach. Scandinavian Journal of Gastroenterology . 2002Testino G, Cornaggia M. P53 protein expression in epithelial high-grade dysplasia from the stomach. Scand J Gastroenterol 2002;37:370-371...
Chen, C WLee, Y CLin, Y MKuo, P LLane DP. On the expression of the p53 protein in human cancer. Molec. Biol. Reports 1994, 19:23-29.Lane DP. On the expression of the p53 protein in human cancer. Molec. Biol. Reports 1994, 19:23-29. [ ...
The Role of Protein Kinase CK2 in the p53 Responsedoi:10.1002/9781118482490.ch6p53Ser392 phosphorylationcancer cellsrole of CK2David W. MeekDivision of Cancer Research, Medical Research Institute, The University of Dundee Ninewells Hospital, Dundee, Scotland, United Kingdom...
The p53 protein integrates cellular stress signals and functions as a transcription factor with many target genes whose transcripts are involved in DNA repair, cell cycle arrest, and activation of the apoptotic programme. So central is p53 to the life and death decisions of every cell that its ...
In proliferating hepatocytes, p53 has been shown to activate downstream signals that maintain hepatocyte prolifera- tion.9 A high level of p53 protein was found in the cytoplasm of mouse embryonic stem cells, where it contributes to the maintenance of self-renewal and induction of proliferation.10...