The p53 tumor suppressor protein is best known as an activator of cell cycle arrest and apoptosis. Only a fraction of p53-activated genes encode proteins affecting cellular replication and various forms of cell death (apoptosis, ferroptosis, autophagy). The p53-regulated genes can be di...
The p53 protein is a transcription factor involved in processes of cell growth and differentiation. The muscle creatine kinase (MCK) gene whose transcription is induced during muscle differentiation contains p53-binding sites. In this study we tested the involvement of p53 in the activation of MCK ...
P53 is a multifunctional protein of 53 kDa, activated in response to various molecular stressors. It is involved in cell cycle arrest in G I and induction of apoptosis, regulation of gene transcription, cell differentiation, angiogenesis, but its primary role is DNA repair. Necessary during molec...
p53 protein at 2 days after 12 Gy, the timepoint when Clu+revSCs first start emerging in the irradiated intestine (Fig.4a, b). However, the expression of p53 protein in intestinal epithelial cells was transient as it was substantially diminished by 3 days after irradiation (Fig.4a, band...
p53 has been the subject of intense research activity over the past 10 years because of its critical role in guarding against cancer development [1]. Although mice deleted for p53 can develop normally, they are highly tumor prone, and loss of p53 strongly enhances tumor development driven by ...
There is an ongoing battle between cancer cells and p53, the protein known as "the guardian of the genome," and a study conducted at the University of Trento has identified a number of factors that influence the outcome of this battle and therefore the e
7)210. Shukla and colleagues demonstrated that the depletion of PARN in HeLa cells affects the levels of numerous miRNAs regulating p53 protein expression. They found that PARN removes oligo(A) tails from either mature miRNAs or pre-miRNAs that were added by the poly(A) polymerase PAPD5 (...
Using stroke-prone spontaneously hypertensive (SH-SP) rats with permanent occlusion of the middle cerebral artery (MCA), we investigated the expression of wild type p53 (wt-p53) protein and the occurrence of DNA fragmentation in cerebral neurons after ischemia. Three days following MCA occlusion, ...
Chen, C WLee, Y CLin, Y MKuo, P LLane DP. On the expression of the p53 protein in human cancer. Molec. Biol. Reports 1994, 19:23-29.Lane DP. On the expression of the p53 protein in human cancer. Molec. Biol. Reports 1994, 19:23-29. [ ...
The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activat