J. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res. 66, 4795-4801 (2006).Yu X, Harris SL, Levine AJ. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res. 2006;66:4795-4801. doi: 10.1158/0008-5472....
Around half of all human cancers carry p53 mutations, and recent studies have suggested that many tumors that retain wild-type p53 are defective in either the ability to induce or the ability to respond to p53. The p53 protein lies at the heart of stress response pathways that prevent the ...
Normal cells contain p53 protein in a latent state that can be activated for sequence-specific transcription by low levels of UV radiation without an increase in protein levels. Microinjection of cells with an antibody specific to the C-terminal negative regulatory domain can activate the function ...
The p53 tumor suppressor protein can be phosphorylated at several sites within the N- and C-terminal domains, and several protein kinases have been shown to phosphorylate p53 in vitro. In this study, we examined the activity of p53 proteins with combined mutations at all of the reported N-ter...
A ChIP-seq analysis of the DNA-binding properties of mutant gain-of-function p53 protein compared to wild-type p53 reveals the gain-of-function proteins bind to and activate a distinct set of genes including chromatin modifying enzymes such as the histon
TP53.Thetumoursuppressionfunctionofp53reliesonitsabilitytoactasapotentsequence-specifictranscriptionalactivator,regulatingaprogramofgeneexpressionthatleadstocellcyclearrest,DNArepairandapoptosis(VousdenandLu,2002).Amongthegenesinducedbyp53isthegeneforthecyclin-dependentkinaseinhibitor,p21WAF1(p21),whichblockscell...
Mechanisms to protect organisms from the consequences of DNA damage include the tumor suppressor p53 pathway. p53 protein binds specifically to a DNA consensus sequence to induce growth inhibitory genes or nonspecifically to damaged sites leading to DNA repair or apoptosis. While p53 protein is suscep...
of p53 protein, which can be attributed to a requirement of DCAF1 for MDM2-mediated p53 poly-ubiquitination. Importantly, p53 deletion rescues the cell cycle entry defect but not the growth defect of DCAF1-deficient cells. Therefore, DCAF1 is vital for T-cell function through p53-dependent ...
PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53 喜欢 0 阅读量: 9 作者: Y C.-H.,L E.-S.,L D.-S.,B Y.-S. 展开 DOI: 10.1073/pnas.0812148106 被引量: 132 年份: 2009 收藏 引用 批量引用 报错 分享 ...
p53 Protein expression or protein function? Re: Awwad et al. IJROBP 34(2):323–332; 1996 - International Journal of Radiation Oncology Biology Physicsdoi:10.1016/0360-3016(96)85887-1Robert G. BristowSam BenchimolRichard HillInternational Journal of Radiation OncologyBiologyPhysics...