The p53 protein has a structure reminiscent of other factors involved in transcription. 1–5 As discussed previously, strong evidence that wild-type p53 functions as a regulator of transcription has come from biochemical and biological studies demonstrating that the protein can repress the interleukin-...
Around half of all human cancers carry p53 mutations, and recent studies have suggested that many tumors that retain wild-type p53 are defective in either the ability to induce or the ability to respond to p53. The p53 protein lies at the heart of stress response pathways that prevent the ...
The p53 tumor suppressor protein is a transcription factor with sequence-specific DNA binding activity that is thought to be important for the growth-inhibitory function of p53. DNA binding appears to require activation of a cryptic form of p53 by allosteric mechanisms involving a negative regulatory...
In this study, we examined whether the aberrant expression and function of p53 protein is also observed in T-cells immortalized by Tax1. We found that p53 with the wild-type conformation was expressed at an elevated level by a post-transcriptional mechanism, and that its trans-activating functi...
The p53 protein responds to stress signals by regulating the transcription of a variety of genes. Some of these genes encode secreted proteins that may be involved in the communication between adjacent cells. In this study, a proteomics approach was employed to identify proteins secreted by cells ...
The structure of this domain (a SAM domain) suggests that it is a protein-protein interaction module that may be involved in developmental processes. The oligomerization domains of p53 family members, while conserved in sequence and three-dimensional structure do not interact appreciably with other ...
Other p53-dependent properties, such as the mitotic spindle checkpoint and permissivity for gene amplification, are also normal in PARP-deficient cells. We conclude that the induced level of the p53 protein is governed by a combination of PARP-dependent and PARP-independent pathways and that the ...
The structure of this domain (a SAM domain) suggests that it is a protein-protein interaction module that may be involved in developmental processes. The oligomerization domains of p53 family members, while conserved in sequence and three-dimensional structure do not interact appreciably with other ...
To repair DSBs, cells have evolved a sophisticated DSB repair system and p53-binding protein 1 (53BP1) plays a predominant role in DSB repair; thereby promoting genomic stability1,2. In response to DSBs; PI3 like kinases, including ATM, ATR, and DNAPK, phosphorylate H2AX in the vicinity ...
p53 Protein expression or protein function? Re: Awwad et al. IJROBP 34(2):323–332; 1996 - International Journal of Radiation Oncology Biology Physicsdoi:10.1016/0360-3016(96)85887-1Robert G. BristowSam BenchimolRichard HillInternational Journal of Radiation OncologyBiologyPhysics...