The role of p53 in cell metabolism. Acta Phar- macol Sin 2010;31:1208-12.X.D. Zhang, Z.H. Qin, J. Wang, The role of p53 in cell metabolism, Acta Pharmacol. Sin. 31 (9) (2010) 1208-1212. http://dx.doi.org/10.1038/aps.2010.151.Zhang XD, Qin ZH and Wang J: The role of...
The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to genotoxic stress. A possible role for p53-related modulation of neuronal viab
A protein called p53 plays a key role in the body's immune response to cancer, and therefore ...
The tumor suppressor protein p53 is a rapid-response transcriptional regulator of numerous pathways involved in maintaining cellular homeostasis. Though extensively researched in the context of cancer and its role in the Warburg effect, few studies have examined the role of p53 in skeletal muscle, an...
[8].Bakhoum S F, Cantley L C. The multifaceted role of chromosomal instability in cancer and its microenvironment[J]. Cell, 2018, 174(6): 1347-1360. [9].Chattopadhyay S, Marques J T, Yamashita M, et al. Viral apoptosis is induced by IRF‐3‐mediated activation of Bax[J]. The EM...
5. Bakhoum, S.F., and Cantley, L.C. (2018). The multifaceted role of chromosomal instability in cancer and its microenvironment. Cell174, 1347–1360.6. Bakhoum, S.F., Ngo, B., Laughney, A.M., Cavallo, J.A., Murphy, C.J., Ly, P., Shah, P., Sriram, R.K., Watkins, ...
[8].Bakhoum S F, Cantley L C. The multifaceted role of chromosomal instability in cancer and its microenvironment[J]. Cell, 2018, 174(6): 1347-1360. [9].Chattopadhyay S, Marques J T, Yamashita M, et al. Viral apoptosis is induced by IRF‐3‐mediated activation of Bax[J]. The EM...
p53 plays a critical role in this pathway by inducing the expression of TP53-induced glycolysis and apoptosis regulator (TIGAR), which acts as a phosphatase that degrades F2,6BP and thereby decreases the activity of PFK1. Hence, p53, via TIGAR, lowers the glycolytic rate and would be ...
CKIα ablation highlights a critical role for p53 in invasiveness control The mature gut renews continuously and rapidly throughout adult life, often in a damage-inflicting micro-environment. The major driving force for self-renewal of the intestinal epithelium is the Wnt-mediated signalling pathway,...
p53 and its mutants in tumor cell migration and invasionJ. The Jour 28、nal of cell biology, 2011, 192(2): 209-218.4. Feng Z, Hu W, De Stanchina E, et al. The regulation of AMPK 1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these...