Rescuing the function of mutant p53 - Bullock, Fersht - 2001Bullok AN, Fersht AR. Rescuing the function of mutant p53 . Nat Rev Cancer. 2001;1:68-76.Bullock, A. N., Fersht, A. R. (2001) Rescuing the function of mutant p53. Nat. Rev. Cancer 1 68: pp. 76...
The p53 protein is a major mediator of the cellular response to genotoxic stress and is a crucial suppressor of tumor formation. In a variety of organisms, p53 and its paralogs, p63 and p73, each encode multiple protein isoforms through alternative splic
Regulation and Modulation of the Function of p53 来自 Semantic Scholar 喜欢 0 阅读量: 18 作者:T Mukhopadhyay,SA Maxwell,JA Roth 摘要: The p53 protein has a structure reminiscent of other factors involved in transcription.1–5 As discussed previously, strong evidence that wild-type p53 functions...
As p53 is such a potent inhibitor of cell growth, its function must be tightly controlled to allow normal growth development. This is achieved through several mechanisms that include regulation of p53 transcription and translation, protein stability, subcellular localization and activity [19]. Rapid ...
The key p53-degrading function of Mdm2 is also conserved in TaMdm2. Tap53 retained DNA binding associated with p53 transcription activation function. However, it lacked transactivation function in reporter genes assays using a heterologous cell line, suggesting a cofactor incompatibility. Overall, the ...
Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic... Harris CC. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996;88:1442-... Harris,Curtis,C. - 《Jnci Journal of the...
which is demonstrably involved in stimulating certain differentiated cell states. In pancreas cancer, the tumor suppressor p53 stimulates the production of αKG and maintenance of a more well-differentiated cell state, whereas prototypical loss of p53 function results in reductions in αKG levels and...
Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy 1999, Oncogene Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90 1996, Proceedings of the National Academy of Sciences of the United States of...
Recent findings indicated that p53 plays an important role in meta- bolic shifting in cancerous cells, suggesting a new function of p53 in regulating cell metabolism. However, how p53 regu- lates metabolism is complicated. In this review, we will try to elucidate the complex network of p53 ...