One such case is DNA repair at the natural ends of linear chromosomes, known as telomeres, which can lead to chromosome-end fusions. Here, we review data obtained over the past decade and discuss the mechanisms that protect mammalian chromosome ends from the DNA damage response. We also ...
P53 is found often in familial melanoma cases. The gene, when it operates normally, helps the body repair mutated cells to prevent, amongst other things, cancer from developing. However when p53 is altered it can’t operate its job properly and allow cancers to grow. Heavy UV light that da...
The p53 pathway is composed of hundreds of genes and their products that respond to a wide variety of stress signals. These responses to stress include apoptosis, cellular senescence or cell cycle arrest. In addition the p53-regulated genes produce proteins that communicate these stress signals to...
What is the role of phospholipase C?Enzymes:The enzymes are the proteinaceous substances which act as a biocatalyst to catalyze a chemical reaction. Enzymes speed up the rate of the reaction without itself being changed in the overall process....
What is the role of healthy fats?Fats:Fats are macronutrients that consist of carbon, and hydrogen atoms. These are insoluble in water and soluble in organic solvents. The examples of fats are cholesterol, triglycerides, and phospholipids.
Although it is unclear whether p53 regulates the same, different, or overlapping pathways in the two experimental systems, these data demonstrate that p53 function is critical for the maintenance of normal growth control and support the current classification of p53 as a growth suppressive or tumor ...
One of the many debated topics in ageing research is whether progeroid syndromes are really accelerated forms of human ageing. The answer requires a better understanding of the normal ageing process and the molecular pathology underlying these rare diseases. Exciting recent findings regarding a severe ...
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn’s disease are two major forms of the disease. IBD imposes a lot of sufferings on the patient and has many consequences; h
TP53, PTEN), since the normal function of these genes is to restrict tumorigenic potential. Loss of heterozygosity (LOH) is a common genetic event in many cancer types, so-called because of the early observations of a change in polymorphic markers from a heterozygous state in the germline to...
In the frameshift of the worldwide increase in chronic, degenerative and inflammatory diseases, it is well-established the crucial role of nutrition in cancer onset, progression, and outcome, and the consumption of healthy foods and nutrients are recognized as a valid strategy for primary cancer pr...