1 The recognition of specific genes that modulate proliferation, has led to studies on the cell cycle. 2 Homeostasis has a great importance in the development of tumors and is regulated by a balance among proliferation, the arrest of growth and programmed death (apoptosis)....
The induction of p53 in response to oncogenes such as Myc, Ras and E2F1 provides an efficient mechanism to prevent the outgrowth of cells that show proliferative abnormalities. However, activation of these same signals is also required for normal cell proliferation and several mechanisms that attenua...
We used a novel, sensitive DNA binding assay to examine p53 proteins in lysates prepared from cells responding to DNA damage. Non-transformed progenitor keratinocytes exhibited rapid and sustained induction of activated p53 protein binding to the consensus sequence, correlated with sustained induction of...
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1 / CDK1⁃phosphorylated nuclear iASPP[ J] .Cancer Cell, 2016, 30 (5) :822-823. 收稿日期:2016-10-02; 修回日期:2016-12-13Lu, M., Breyssens, H., Salter, V., et al. (2013). Restoring p53 function in...
& Oren, M. Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature 312, 646–649 (1984). Article CAS Google Scholar Parada, L.F., Land, H., Weinberg, R.A., Wolf, D. & Rotter, V. Cooperation between gene encoding p53 tumour antigen and ras ...
We have exploited this loss of p53 function in the regulation of gene transcription to develop a novel gene therapy strategy that maximizes expression of the potential therapeutic gene in tumors while simultaneously down-regulating the same gene in normal cells. In one construct (unit I), the ...
Besides, inhibiting AKT/mTOR pathway significantly suppressed PD-L1 expression, tumor growth, and immune escape in p53 mutated cells. In conclusion, mutant p53 achieved its Gain-of-Function by transcriptionally inhibiting PHLPP2 and activating AKT, which suppresses immune response and advances tumor ...
Background We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranormal levels, cyclin B1-dependent kinase is activated,...
Normal cells contain p53 protein in a latent state that can be activated for sequence-specific transcription by low levels of UV radiation without an increase in protein levels. Microinjection of cells with an antibody specific to the C-terminal negative regulatory domain can activate the function ...
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