Normal cells contain protein in a latent state that can be activated for sequence-specific by low levels of UV radiation without an increase in protein levels. Microinjection of cells with an antibody specific to the C-terminal negative regulatory domain can activate the function of as a ...
Extracellular matrix induces doxorubicin-resistance in human osteosarcoma cells by suppression of p53 function. Cancer Biol Ther 6, 1240-1246.Harisi R, Dudas J, Nagy-Olah J, Timar F, Szendroi M, Jeney A. Extracellular matrix induces doxorubicin-resistance in human osteosarcoma cells by ...
Notch-1 signals appear to be critical for the very early steps of T-cell development (i.e. T-cell commitment).19 The involvement of p53 has been instead reported in the transition from the DN to the DP stage. However, while the over- expression of p53 during DN3 stage promotes a ...
Background We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranormal levels, cyclin B1-dependent kinase is activated,...
We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranormal levels, cyclin B1-
The induction of p53 in response to oncogenes such as Myc, Ras and E2F1 provides an efficient mechanism to prevent the outgrowth of cells that show proliferative abnormalities. However, activation of these same signals is also required for normal cell proliferation and several mechanisms that attenua...
Mutation of p53 is the most common genetic change in human cancer, causing complex effects including not only loss of wild-type function but also gain of novel oncogenic functions (GOF). It is increasingly likely that p53-hotspot mutations may confer dif
In addition to pro-apoptotic molecules such as p53, TAp73 and TAp63, this gene family also encodes for the anti-apoptotic molecules deltaNp73, deltaNp63, deltaNp53, and p53 mutants are often found in tumor cells, that have the role to limit and to modulate the pro-apoptotic side of ...
These results suggested that tri-phosphorylation at the acidic tail indeed impairs HMGA1a-P53 interaction and acts as a transcriptional modulator of P53 in cells. Conformational change of HMGA1a upon phosphorylations To further investigate the underlying mechanism, we first mapped the protein binding ...
p53 is mutated in over half of human cancers. In addition to losing wild-type (WT) tumor-suppressive function, mutant p53 proteins are proposed to acquire gain-of-function (GOF) activity, leading to novel oncogenic phenotypes. To study mutant p53 GOF mec