Phillip HS. The role of p53 in cell cycle regulation. Path Res Pract ,1996 ,192 (7) :669Shaw PH (1996) The role of p53 in cell cycle regulation. Pathol Res Pract 192:669±675Shaw, P. 1996. The role of p53 in cell cycle regulation. Pathol.Res.Pract. 192 :669-675....
In addition, p53 regulates autophagy to provide cell metabolites for surviving through damage regulated autophagy modulator (DRAM1). Here we review the recent findings to elucidate the important role of p53 in cell metabolism. Keywords: tumor suppressor 53; glycolysis; oxidative phosphorylation; TP53-...
In particular, the mechanisms of p53's control of the cell cycle, genomic stability, and apoptosis are reviewed and the way loss of these functions plays a role in tumor cell progression. The chapter discusses the biochemical ... MRA Mowat - 《Advances in Cancer Research》 被引量: 147发表...
These studies thus indicate a role for Tnv-6 in inhibiting the later stages of autophagy in activated CLL cells. Tnv-6 delays ubiquitin–proteasome signalling As the inhibition of autophagy associates with the delayed clearance of substrates through the ubiquitin–proteasome pathway (Korolchuk et al...
【关键词】子宫内膜肿瘤;蛋白质P53;受体,雌激素;受体,孕酮 中图分类号:R737.33文献标识码:A文章编号:1004-7379(2001)06-0414-03 ExpressionofcellcycleregulatoryP53,P16,P21andRbinendometrialcarcinoma.Wang Liming,LuCailian,JiXiangrui,etal.DepartmentofGynecology,theAffiliatedofMedical College,QingdaoUniversity,Qing...
The role of p53 in tumour suppression: lessons from mouse models tumour suppressor genecancerapoptosiscell-cycle arrestThe use of mouse models has greatly contributed to our understanding of the role of p53 in tumour ... LD Attardi,T Jacks - 《Cellular & Molecular Life Sciences Cmls》 被引量...
(2019). Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov, 5, 7. https://doi.org/10.1038/s41421-018-0070-x Article CAS PubMed PubMed Central Google Scholar Carr, S. M., Munro, S., ...
More recently, we have shown that the dynamics of p53 play a role in the specificity of the response with pulsed p53 favoring DNA repair and cell-cycle arrest genes and sustained p53 triggering activation of senescence and apoptotic genes (Batchelor et al., 2011, Purvis et al., 2012). The...
Biology of the CellDavid-Pfeuty T, Chakrani F, Ory K, Nouviandooghe Y. Cell cycle-dependent regulation of nuclear p53 traffic occurs in one subclass of human tumor cells and in untransformed cells. Cell Growth Differ. 1996; 7 :1211–1225....
The phosphorylation of proteins on tyrosine: its role in cell growth and disease The reversible phosphorylation of tyrosines in proteins plays a key role in regulating many different processes in eukaryotic organisms, such as growth con... Hunter,T. - 《Philos Trans R Soc Lond B Biol Sci》 ...