(2006). Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell 10: 437–449. Article CAS PubMed Google Scholar Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI . (2005). Alpha...
· p53 stimulation- This is a transcription factor that is produced in the event of DNA damage · POMC expression- p53 influences increased expression of the protein POMC (Pro-opiomelanocortin). Pro-opiomelanocortin is the precursor to several hormones including Alpha-MSH (Alpha melanocyte-stimulating...
this cytoskeletal protein may participate in cytoplasmic anchorage of p53 during senescence [15], thus making it unavailable for its transcriptional targets and, as a consequence, limiting its nuclear-dependent tumor suppressor functions and downstream pathways of cell death and/or cell cycle arrest. ...