Mary O'NeillPeter A. HallHumana PressCampbell SJ, O'Neill M, Hall PA, 1999: Function of the p53 gene family: a holistic perspective. In: Hickman JA, Dive C (eds) Apoptosis and cancer chemotherapy. Humana Press, Totowa, New Jersey, 1999, p:53-68...
These advances have brought with them the realization that there are many ways to perturb the p53 pathway during tumor development, in addition to the commonly seen mutation within the p53 gene itself. These include loss of the ability to stabilize p53, through mechanisms such as loss of ARF ...
PKR, a p53 target gene, plays a crucial rolein the tumor-suppressor function of p53Cheol-Hee Yoona, Eun-Soo Leea, Dae-Seog Limb, and Yong-Soo Baea,b,1aDepartment of Biological Sciences, Sungkyunkwan University, Choenchoen-Dong, Jangan-Gu, Suwon, Gyeonggi-Do 440-746, South Korea and...
TP53.Thetumoursuppressionfunctionofp53reliesonitsabilitytoactasapotentsequence-specifictranscriptionalactivator,regulatingaprogramofgeneexpressionthatleadstocellcyclearrest,DNArepairandapoptosis(VousdenandLu,2002).Amongthegenesinducedbyp53isthegeneforthecyclin-dependentkinaseinhibitor,p21WAF1(p21),whichblockscell...
We conclude that the induced level of the p53 protein is governed by a combination of PARP-dependent and PARP-independent pathways and that the activation of p53 is largely PARP-independent. The results are consistent with a model in which the regulation of gene expression by p53 involves both...
TP53(which encodes p53 protein) is the most frequently mutated gene among all human cancers. Prevalent p53 missense mutations abrogate its tumour suppressive function and lead to a ‘gain-of-function’ (GOF) that promotes cancer. Here we show that p53 GOF mutants bind to and upregulate chromatin...
Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53. Activation of p53 by genotoxic stress induces a significant level of PKR expression by acting on the newly identified cis-acting element (ISRE), which is separated from the ...
Oncogenic forms of p53 inhibit p53 regulated gene expression Science, 256 (1992), pp. 827-830 Google Scholar Kuerbitz et al., 1992 S.J. Kuerbitz, B.S. Plunkett, W.V. Walsh, M.B. Kastan Wild type p53 is a cell cycle checkpoint determinant following irradiation Proc. Natl. Acad. Sci...
PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53 喜欢 0 阅读量: 9 作者: Y C.-H.,L E.-S.,L D.-S.,B Y.-S. 展开 DOI: 10.1073/pnas.0812148106 被引量: 132 年份: 2009 收藏 引用 批量引用 报错 分享 ...
and p53 mutant-positive PCa cell growth in vitro and in mice. Our study identifies a gene transactivation function of GOF mutant p53 and reveals β-Catenin as a transcriptional target gene of p53 GOF mutants and a driver and therapeutic target of TMPRSS2-ERG- and p53 GOF mutant-positive ...