Mary O'NeillPeter A. HallHumana PressCampbell SJ, O'Neill M, Hall PA, 1999: Function of the p53 gene family: a holistic perspective. In: Hickman JA, Dive C (eds) Apoptosis and cancer chemotherapy. Humana Press, Totowa, New Jersey, 1999, p:53-68...
9047/15 www.nature.com/cdd Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53 HJ Lee1, JM Kim1, KH Kim2, JI Heo3, SJ Kwak4 and JA Han*,1 DNAJB9 is a recently isolated member of the molecular chaperone gene family, whose precise function is largely ...
PKR, a p53 target gene, plays a crucial rolein the tumor-suppressor function of p53Cheol-Hee Yoona, Eun-Soo Leea, Dae-Seog Limb, and Yong-Soo Baea,b,1aDepartment of Biological Sciences, Sungkyunkwan University, Choenchoen-Dong, Jangan-Gu, Suwon, Gyeonggi-Do 440-746, South Korea andbCre...
Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. 1996. Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies. J. Natl. Cancer Inst. 88: 1442-1455... C C,Harris - 《Journal of the Nat...
and p53 mutant-positive PCa cell growth in vitro and in mice. Our study identifies a gene transactivation function of GOF mutant p53 and reveals β-Catenin as a transcriptional target gene of p53 GOF mutants and a driver and therapeutic target of TMPRSS2-ERG- and p53 GOF mutant-positive ...
These advances have brought with them the realization that there are many ways to perturb the p53 pathway during tumor development, in addition to the commonly seen mutation within the p53 gene itself. These include loss of the ability to stabilize p53, through mechanisms such as loss of ARF ...
Our findings show for the first time that PXR expression modulates p53 target gene promoter binding and contributes to the downregulation of p53 function in human colon cancer cells. These results define the functional significance of PXR expression in modulating p53-mediated mechanisms of tumor ...
We also demonstrated the capacity for GOF p53 protein to be transferred from tumor cells to normal fibroblasts. By investigating the change in gene expression in fibroblasts after treatment with small EVs with or without GOF p53 protein, we observed that expression of multiple CAF-associated genes ...
The p53 protein is a major mediator of the cellular response to genotoxic stress and is a crucial suppressor of tumor formation. In a variety of organisms, p53 and its paralogs, p63 and p73, each encode multiple protein isoforms through alternative splic
Millions of people are living with cancer having specific mutation in p53 gene while every single person is truly unique in genetic basis or clinical manifestation. The gene encodes transcription factor p53, which plays a central role in regulating cell cycle progression, senescence, differentiation, ...