Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Blood 1999; 94: 1755-1760.Montesinos-Rongen M, Roers A, Kuppers R, Rajewsky K, Hansmann ML. Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg ...
We previously reported that introduction of the wild-type p53 gene into human cancer cells with deleted p53 enhanced apoptosis induced by chemotherapy [Fujiwara et al. (1994) Cancer Res 54:2287]. This suggests that p53 status could be a potent determinant of the therapeutic efficacy of DNA-dama...
结果1 题目According to the passage, p53 is ___. A. a protein to prevent cancer B. a gene to defend against cancer C. a protein to destroy damaged cells D. a gene to change cells 相关知识点: 试题来源: 解析 B 反馈 收藏
- 1992 - 123 - www.sciencedirect.comdoi:10.1016/0169-5002(92)90119-5NoneLung Cancer
P53 gene mutations are not the primary cause of protein overexpression--an alternative mechanism is responsible for the positive p53 immunohistochemistry detected. 展开 关键词: oesophageal adenocarcinoma p53 mutations deletion expression immunohistochemistry ...
We addressed this question by characterizing the transcriptional response to inhibition of PI 3-kinase in Rat-1 cells, which have a normal Tp53 gene,31,32 compared with Rat-1 cells expressing a dominant-negative p53 mutant. Analysis of apoptosis and gene regulation in these cells indicates that...
ObjectiveEndometriosis is inherited as a complex trait, which means that multiple susceptibility genes interact with each other and the environment to produce the phenotype. Previous studies have implicated p53, a tumor suppressor gene, as a factor in the development of the disease. In a Japanese ...
FLJ11259 is regulated by DNA damaging agents in various cell lines in a p53-dependent manner, and p53 directly binds to an upstream element in the FLJ11259 gene. FLJ11259 was observed to localize in a punctate pattern throughout the cytoplasm. Stable overexpression of FLJ11259 in Cos-7, Sao...
AIMS: To attempt to detect p53 gene mutations in the plasma of patients with large bowel carcinoma. METHODS: Plasma was collected from 20 control patients with no history of cancer and from 17 patients with large bowel carcinoma. Corresponding tumour and benign lymph node (control) samples for ...
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a common and crucial event in carcinogenesis. Mutatio...