What is the p53 GeneŠvihálkováŠindlerová, LMachala, MPěnčíková, KMarvanová, SNeča, JTopinka, JSevastyanova, OKozubík, AVondráček, J
the first production of gene therapy products - recombinant human p53 anti-cancer injection; In 2007, echinoderm microtubule associated protein like 4-anaplastic lymphoma kinane (4-alk) was found in lung cancer patients, which has greatly promoted the development of its specific inhibitor crizotinib....
P53 is found often in familial melanoma cases. The gene, when it operates normally, helps the body repair mutated cells to prevent, amongst other things, cancer from developing. However when p53 is altered it can’t operate its job properly and allow cancers to grow. Heavy UV light that da...
Sox2, a key factor in the regulation of pluripotency and neural differentiation. World J. Stem Cells 6, 305–311 (2014). PubMed PubMed Central Google Scholar Rudin, C. M. et al. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat....
et al. A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families. Nat. Commun. 6, 8383 (2015). CAS PubMed Google Scholar Aoude, L. G. et al. Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. ...
it helps promote the development of Barrett’s esophagus. However, it also protects cells against the loss of another key gene encoding p53 – a critical tumor suppressor often dubbed the ‘guardian of the genome’. Loss of p53 strongly drives the progression of disease from Barrett’s to canc...
What is an example of a genetic mutation or an evolutionary process which can be seen to increase the information in the genome?What is the difference between RAD9 and P53 gene mutations?What type of mutation occurs in non-reproductive cells and cannot be passed onto offspring?
What are some environmental mutagens that can cause gene mutations in humans? What is somatic mutation? Explain the three types of DNA mutations and explain the possible outcomes of each mutation. What is the difference between RAD9 and P53 gene mutations?
1A). Restricted to primates, alternative splicing of the H2AFV gene produces an isoform called H2A.Z.2.2, which has a shortened and unique C terminus. This alteration leads to destabilization of the nucleosome structure when H2A.Z.2.2 is incorporated into chromatin (15, 16). Download: ...
P53 binds to Puma-promoter gene sites, leading to puma production. The mtCLIC, a member of intracellular chloride channels, is a cytoplasmic and mitochondrial protein positively regulated by p53. Caspase 10 is induced in p53-dependent manner leading to cellular apoptosis. Other newly announced ...