The product of the p53 tumour suppressor gene is a sequence-specific DNA-binding protein that acts as a transcription factor and can inhibit transformation in vitro. Mutational inactivation of p53 is the most frequent genetic alteration found in human cancer. Point mutations of the p53 gene have ...
p53 is a tumour suppressor protein involved in the regulation of the cell cycle. Mutation of the p53 gene and expression of mutant p53 protein are associated with many types of human neoplasia. Mutational hot spots at specific amino acid residues have been identified, and these hot spot ...
By analogy, one might suppose that tumor suppressor gene products fulfil similarly essential functions in the integration process. Although this is probably the case for almost all tumor suppressor genes, there may be one exception: p53. The phenotypes of loss-of-function (‘knock-out’) mutant ...
Inactivation of the p53 tumor suppressor gene product by binding to the HPV encoded E6 protein is considered as an important pathway for malignant progress in HPV-infected cells. In contrast, mutations of the p53 gene have been found in HPV-negative cervical carcinoma cells. To evaluate the ...
p53 is essential for the elimination of neural progenitor cells that fail to differentiate appropriately Mice that carry a null mutation in the p53 gene are born and survive until early adulthood, when they succumb to a variety of tumors,6 an observation that initially led to the conclusion that...
Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells. The wild-type (wt) -suppressor gene product, , and its mutant form have been analysed in an in vivo system in which the inducible expression of wt results ... S ...
p53 is the most commonly mutated gene in human cancers. Approximately 90% of the p53 gene mutations are localized between domains encoding exons 5 to 8. Sequencing methods currently available are tedious and time-consuming and are not suitable for routine laboratory testing. In an effort to ident...
Mutations in the p53 gene usually result in p53 protein stabilization and accumulation; so that the gene product can be detected by immunohistochemistry. ... M Sarbia,F Borchard,HE Gabbert,... - 《Cancer》 被引量: 854发表: 1994年 Ser-249 p53 mutations in plasma DNA of patients with hepa...
可能您是非常英俊的,可能您是非常逗人喜爱的,我可能爱以您。 [translate] aSo, I'm glad to meet you, 如此,我是高兴遇见您, [translate] aThe P53 tumor suppressor gene product is a transcription factor involved in DNA repair. P53肿瘤遏抑器基因产品是在脱氧核糖核酸修理介入的副本因素。 [translate] ...
This is consistent with the view that the Rb-1 gene product plays a general role in the maturation of precursor cells. In contrast, mice heterozygous for a null allele of p53 are predisposed to a spectrum of tumours, while the corresponding homozygotes are viable but show a very high ...