The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly those that cause DNA damage. P53 forms...
How does rapamycin work? Rapamycin does quite a number of things in the cell, but a lot of its effects [involve] slowing down growth and slowing down cell metabolism, which is why it has an impact on aging. Your grandmother lived to be103 years old. Did she take rapamycin, or was her...
Controlling Growth Through the Cell Cycle How does one eukaryotic cell become two? In all eukaryotic cells, the process of duplication occurs within the context of a cell cycle-an ordered series of events through which each cell must pass in order to replicate. In the cell cycle, thou- ...
So the drug concentration remains constant and does not dilute when urine production is increased [58]. Sometimes, a fast release rate is desired, accompanied with enhanced solubility and penetration of non polar drugs. For example, Hibiscus rosa-sinensis and Murraya koenigii extracts are acclaimed...
3. How does the balance of pro and anti-inflammatory cytokines/chemokines change in inflamm-ageing? 4. Age-related changes in the levels of specific cytokines-chemokines 5. The intriguing case of centenarians 6. Nutrition and modulation of inflame-ageing 7. Conclusions Declaration of Competing Inte...
High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities Abnormalities of the p53 gene are known to confer detrimental effects in chronic lymphocytic leukaemia (CLL) and are associated with short survival. We hav... P Thornton,E Matutes,A Bosanquet,... - 《Annals...
In testing for starch in a green leaf, what effect did the boiling water have on the leaf? What effect does ouabain have on tonicity? Describe the significance of p53. Provide a hypothesis of research that could be conducted to furthe...
However, deletion of Nkx2-1 in adult lung does not induce adenoma.53,54 Therefore, inactivation of Nkx2-1 appears to be involved not only in tumor initiation but also in the transition from adenoma to mucinous adenocarcinoma, although deletion of Nkx2-1 alone does not result in the ...
Furthermore, hTERT alone does not always suffice, many cell types require a combination of both methods, TERT DNA and Viral Oncogenes. For example, recent studies have found that co-expression of the hTERT catalytic subunit with either the p53 or RB siRNA can immortalize human primary ovarian ...
And vice versa, how does cancer treatment affect the microbiome and the further path to recovery? How can the microbiome as a biomarker be integrated into everyday diagnostics in order to better the current tools? How can personalized dietary guidelines for recovering CRC patients become a reality...