This article reports that P53 is a tumor suppressor gene. Researchers found that the SV40 T-antigen was bound to a cellular protein that came to be called p53 and that the concentration of the p53 protein was much higher in SV40 or other transformed cells than in normal cells. In fact, ...
A functionally inactive p53 protein in embryonal carcinoma cells is activated by DNA damage or cellular differentiation Nat. Med., 2 (1996), pp. 804-810 View in Scopus Google Scholar Munroe, et al, 1988 Munroe D.G., Rovinski B., Bernstein A., Benchimol S. ...
The/gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mousegene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Radiation-induced lymphomas from p53mice, but not tho...
Mice lacking p53 are of obvious value in studying the role of p53 and other oncogene and tumour suppressor gene products in multistep carcinogenesis. These mice might also help in the experimental dissociation of the transforming potential of mutant p53 protein from its dominant-negative effect on ...
ObjectiveEndometriosis is inherited as a complex trait, which means that multiple susceptibility genes interact with each other and the environment to produce the phenotype. Previous studies have implicated p53, a tumor suppressor gene, as a factor in the development of the disease. In a Japanese ...
p53抑癌基因产物是一种转录因子,参与DNA修复。 翻译结果2复制译文编辑译文朗读译文返回顶部 P53肿瘤抑制基因产品是一种誊写个因素涉及在脱氧核糖核酸的修复。 翻译结果3复制译文编辑译文朗读译文返回顶部 P53 肿瘤抑制基因产物是参与 DNA 的转录因子修复。 翻译结果4复制译文编辑译文朗读译文返回顶部 P53肿瘤抑制基因产品是...
AMID, also called PRG3, is an AIF-homologous and mitochondria-associated protein that has been implicated in caspase-independent apoptosis. In this report, we demonstrated that human AMID gene promoter was activated by p53 in reporter gene assays. Chromatin immunoprecipitation experiments indicated that...
Mechanisms that inactivate the p53 pathway in Acute Myeloid Leukemia (AML), other than rare mutations, are still not well understood. We performed a bioinformatics study of the p53 pathway function at the gene expression level on our collection of 1153 p
E2F4 repression complexes EK Benson1, SK Mungamuri1, O Attie2, M Kracikova1, R Sachidanandam2, JJ Manfredi1 and SA Aaronson1 The p53 tumor suppressor protein is a major sensor of cellular stresses, and upon stabilization, activates or represses many genes that control cell fate decisions....
Here, we show that expression of the immunoregulatory protein CD200 increases as murine dendritic cells (DCs) undergo apoptosis. We defineCD200as a p53-target gene and identify both p53- and caspase-dependent pathways that control CD200 expression during apoptosis. CD200 expression on apoptotic ...