The complex process of cell immortalization and transformation is likely to involve the inactivation of growth regulatory genes. Mutations (deletions, missense mutations) in the p53 gene are the most frequently observed genetic alteration in human tumors, making p53 a candidate for a cellular protein ...
Training intensity modulates changes in PGC-1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle. FASEB J. 2016;30:959–70. Article CAS PubMed Google Scholar Wiewelhove T, Fernandez-Fernandez J, Raeder C, et al. Acute ...
Mechanism of glycolysis in renal fibrosis Full size image Similarly, AA metabolism is essential in renal fibrosis. As the most abundant AA in the body and a substrate for protein synthesis, glutamine is involved in several metabolic pathways and plays a particularly crucial role in renal fibrosis....
IBD is a general term mainly referred to two categories of chronic inflammatory disorders of gastro-intestinal tract including Crohn's disease and Ulcerative colitis [1]. Crohn’s disease and Ulcerative colitis have very similar pathogenesis, and both can cause chronic bowel inflammation. IBD is dev...
In mammals, telomeres are composed of TTAGGG repeats, which are bound by a protein complex termed shelterin. Cell divisions lead to the progressive erosion of telomeric repeats. When telomeres become too short to recruit the shelterin complex, they become dysfunctional, leading to telomere ...
He’s also seen research showing that the spike protein from COVID-19 shots can enter the nucleus and disrupt regulation of p53 and BRCA1 genes:14 “People are probably familiar with BRCA1 because of breast cancer genes, but p53 is also another guardian of the genome. These are genes that...
What is somatic mutation? Mutation: A mutation can be described as the change in the nucleotide sequence of a gene, which is responsible for resulting in either the formation of a defective protein or no protein at all. The mutation can also alter the regulation of certain genes leading to ...
What types of fats are generally considered detrimental to your health? What is MDM2 and how does it affect the P53 protein? Why are unsaturated fats unhealthy? Describe the composition of triglycerides. How does the saturation state of the hydrocarbon tail groups influence membrane...
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn’s disease are two major forms of the disease. IBD imposes a lot of sufferings on the patient and has many consequences; h
To provide deeper insight into functions of this special cell surface sub-proteome, pathway enrichment analysis of the determined CHO surfaceome was conducted. Enrichment of growth/ survival-pathways such as the phosphoinositide-3-kinase (PI3K)–protein kinase B (AKT), mitogen-activated protein ...