p53 isoformstumourIntroduction: For decades, p53 was researched as a single protein with alterations described as mutants. The discovery of 12 human p53 isoforms expressed from 9 transcripts changed this perception, eloquently explaining the numerous roles p53 plays, including apoptosis, senescence and ...
TP53 tumor protein p53 YAP/TAZ Yes-associated protein/transcriptional coactivator with PDZ-binding motif YEATS Yaf9, ENL, AF9, Taf14 and Sas5 ZNHIT1 zinc finger HIT-type containing 1 C. David Allis: “Every amino acid matters”—Spot-on characterization of histone variants In January 2023, ...
HPV is a major cause of cervical cancer that acts by inserting its DNA into the cells of the host. The resulting DNA produces a protein (p53-binding protein) that prevents p53 from mutation repair and tumor suppression. In HeLa cells, this was shown to contribute to changes in microRNA ...
How does the p53 protein protect the body from cancer, and how could the p53 protection mechanism negatively influence longevity? Explain the process of cancer and the effects on the human body. What biological process lead to the weakening of the bones in old age?
In mammals, telomeres are composed of TTAGGG repeats, which are bound by a protein complex termed shelterin. Cell divisions lead to the progressive erosion of telomeric repeats. When telomeres become too short to recruit the shelterin complex, they become dysfunctional, leading to telomere ...
Mechanism of glycolysis in renal fibrosis Full size image Similarly, AA metabolism is essential in renal fibrosis. As the most abundant AA in the body and a substrate for protein synthesis, glutamine is involved in several metabolic pathways and plays a particularly crucial role in renal fibrosis....
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P53 binds to Puma-promoter gene sites, leading to puma production. The mtCLIC, a member of intracellular chloride channels, is a cytoplasmic and mitochondrial protein positively regulated by p53. Caspase 10 is induced in p53-dependent manner leading to cellular apoptosis. Other newly announced ...
He’s also seen research showing that the spike protein from COVID-19 shots can enter the nucleus and disrupt regulation of p53 and BRCA1 genes:14 “People are probably familiar with BRCA1 because of breast cancer genes, but p53 is also another guardian of the genome. These are genes that...
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