The human p53 tumor suppressor gene TP53 is mutated at a high frequency in sporadic breast cancer, and Li-Fraumeni syndrome patients who carry germline mutations in one TP53 allele have a high incidence of breast cancer. In the 10 years since the first knockout of the mouse p53 tumor ...
Jr et al. Small cell lung cancer: can recent advances in biology and molecular biology be translated into improved outcomes? J. Thorac Oncol. 11, 453–474 (2016). This article is an excellent summary of the data presented at an international meeting on SCLC. PubMed PubMed Central Google ...
Despite decades of research, the extent to which human progerias resemble accelerated ageing is still unclear and highly debated. To understand this connection, an ongoing characterization of genetic pathways that influence the ageing process in model systems and investigations into molecular pathways that...
What is p53? What is pRB? How are they involved in cancer? What are their pathways and why do cancer cells need to lose both P53 and pRB? What is nuclear pollution? What is the role of the survivin gene in cancer? What factors increase the risk of prostate cancer?
What is one example of an epigenetic change? What is the only way to produce new alleles? Do mutations always result in a change in the final protein product? Explain. What is meant by the term mutation in biology? What is a dominant negative mutation, and how can it...
2.2 Cell Biology Cell biology is the study of a cell as an individual unit, exploring physiological processes and mechanisms that allow life processes to operate at the molecular level, including cellular structure, division, energy exchange, signaling pathways, and more. Cell biology research studies...
Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 960)) 21k Accesses 19 Altmetric Abstract Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated...
Cellular senescence is a state of stable cell cycle arrest. Cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.
However, in certain cases, the activity of these pathways can lead to aberrant DNA repair, genomic instability and tumorigenesis. One such case is DNA repair at the natural ends of linear chromosomes, known as telomeres, which can lead to chromosome-end fusions. Here, we review data obtained ...
) Expression of p53 in luminal and glandular epithelium during the growth and regression of rat uterus during the estrous cycle. Mol Reprod Dev 61, 445–452. Crossref PubMed Miller SJ, Lavker RM and Sun TT ( 2005) Interpreting epithelial cancer biology in the context of stem cells: ...