- 《Molecular & Cellular Biology》 被引量: 588发表: 2007年 Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function. Kaposi's sarcoma-associated herpesvirus (KSHV) is predominantly associated with three human ...
with a particular focus on the clinical importance of genetic alterations (BRAF mutation, RET/PTC rearrangement, NAD(P)H and NRH polymorphisms and TERT mutation) and anomalous expression of several molecules (P53, P27, COX-2, EGFR, ki-67, S100A4, cyclin D1, galectin-3, HMWK, CK-19, HB...
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However, in certain cases, the activity of these pathways can lead to aberrant DNA repair, genomic instability and tumorigenesis. One such case is DNA repair at the natural ends of linear chromosomes, known as telomeres, which can lead to chromosome-end fusions. Here, we review data obtained ...
We report here that the negative cell cycle regulator protein p53 is an in vivo and in vitro substrate for protein kinase C, a cellular receptor for the tu... J Baudier,C Delphin,D Grunwald,... - 《Proc Natl Acad Sci Usa》 被引量: 743发表: 1993年 S100B in brain damage and neurode...
The main retinal vessels form 2 capillary plexuses: the superficial capillary network, which is found within the nerve-fiber layer, and the deep capillary network lying between the boundary of the inner nuclear layer and the outer plexiform layer. Due to the connections in bloodflow between these...
The aim of this review is to present the interest in using cytological and/or liquid biopsies as complementary biological material, or as an alternative to tissue specimens, for detection at diagnosis of new predictive biomarkers of NS-NSCLC. Keywords: lung cancer; biomarkers; cytology; liquid ...
What is the promoter region? Where is it found? What is its role? What are the role stipulations of an ecologist and an environmental scientist? What is the role of the Board & CEO/President in a hospital? Explain. What is the role of statistics in biology?
Evolutionary biology is a branch of biology that deals with the study of evolution or how modern-day organisms arose, developed, and diversified from ancestral organisms. Evolution also deals with how the different traits and characteristics of extant organisms developed over time. Charles Darwi...
et al. Mevalonate metabolism regulates basal breast cancer stem cells and is a potential therapeutic target. Stem Cells 30, 1327–1337 (2012). Article CAS PubMed Google Scholar Rangarajan, A. & Weinberg, R. A. Comparative biology of mouse versus human cells: modelling human cancer in mice....