p53 isoformstumourIntroduction: For decades, p53 was researched as a single protein with alterations described as mutants. The discovery of 12 human p53 isoforms expressed from 9 transcripts changed this perception, eloquently explaining the numerous roles p53 plays, including apoptosis, senescence, and...
Why do many of the most common cancers target the reproductive system? How does the p53 protein protect the body from cancer, and how could the p53 protection mechanism negatively influence longevity? Explain the process of cancer and the effects on the human body. ...
The core p53 functions, the downstream genes regulated by p53 and the outputs of the p53 pathway. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene...
HPV is a major cause of cervical cancer that acts by inserting its DNA into the cells of the host. The resulting DNA produces a protein (p53-binding protein) that prevents p53 from mutation repair and tumor suppression. In HeLa cells, this was shown to contribute to changes in microRNA ...
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36, 618–623 (2004). CAS PubMed Google Scholar Ye, J. Z. et al. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev. 18...
What is MDM2 and how does it affect the P53 protein? What is the impact of obesity on the nervous system? What are the disadvantages of using hip resurfacing implants? Describe the process of vaccination for measles. Why is it effective?
Wiley has the first hints of why those cells lose their normal zest to divide. Great grandpups of irradiated mice had elevated levels of the tumour-suppressor protein p53. This halts cell division, giving time to repair mutations. “It seems these animals have...
Transformation related protein 53, encodes the p53 protein XXM: XX gonadal male XYM: XY gonadal male XXF: XX gonadal female XYF: XY gonadal female References Abel JM, Witt DM, Rissman EF (2011) Sex differences in the cerebellum and frontal cortex: roles of estrogen receptor alpha an...
What is the function of a protein?Food and Nutrition:All living things require essential food and nutrients needed for proper growth and development. Food taken by man and animals is classified into three main categories. These include foods that produce energy when broken down, foods that are ...
What is the one side effect of alpha blockers that beta blockers do not have? What is MDM2 and how does it affect the P53 protein? (A) What factors regulate the release of prolactin? (B) What are the clinical effects of hyperprolactinemia? (C) What are the causes of hyperprol...