(2007) Sustained elevations in NEFA induce cyclooxygenase-2 activity and poten- tiate THP-1 macrophage foam cell formation. Atherosclerosis 192, 49-55.Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ. Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam ...
CCL2/CCR2 gene knockout mice and macrophage-specific PPARG gene knockout mice were respectively used to investigate the role of infiltration and polarization of TAMs in ESCC. CCL2-mediated monocyte chemotaxis was estimated in malignantly transformed Het-1A cells. THP-1 cells were used to ...
Upconversion nanoparticle-mediated pho- todynamic therapy induces THP-1 macrophage apoptosis via ROS bursts and activation of the mitochondrial caspase pathway. Int J Nanomedi- cine. 2015;10:3719–36. 32. Zhou Y, Yu Q, Qin X, et al. Improving the anticancer efficacy of laminin receptor-...
plantarum-derived EVs (LEVs) exert beneficial effects on human skin by examining the effect of LEVs on cutaneous immunity, particularly on macrophage polarization. LEVs promoted differentiation of human monocytic THP1 cells towards an anti-inflammatory M2 phenotype, especially M2b, by inducing biased ...
The activation of PPAR-α may promote foam-cell formation by inducing expression of the macrophage scavenger receptor CD36. This prompted us to investigate the influence of different PPAR- activators on cholesterol metabolism and foam-cell formation of human primary and THP-1 macrophages. Here we ...
Hypertension is one of the most important cardiovascular risk factors and results in macrophage infiltration of blood vessels. However, how macrophages coordinate inflammatory responses with endothelial cells (ECs) remains unclear. In this study, we inve
c, d The overexpression of MT1F and MT2A in THP-1 and U937 cells induced pro-repair macrophages polarization. e, f The knockdown of MT1F and MT2A in THP-1 and U937 cells had no effect on macrophage polarization. Data represent the mean value ± SEM of five individual experiments ...
THP1 cells in the presence of antigen. The control ADC remained cell surface-bound regardless of the antigen presence, and the Fc mutant targeted ADC-treated THP1 cells were negative for both FITC and PE, confirming the lack of binding to the cells. These results indicate that ADCs bind to...
This result was in agreement with a strong activation of phagocytosis in cocultured THP-1 macrophages. Interestingly, HC-treated Jurkat cells led to an early (3.5 h) but transient increase in TNF-α levels in macrophage coculture. Release of TGF-β remained unaffected after 18 h. We propose...
FcRn colocalized in vivo with macrosialin (CD68) and Ncl-Macro, two macrophage markers, in the lamina propria of human small intestine. The heavy chain of FcRn was associated with the beta(2)-microglobulin (beta(2)m) light chain in U937 and THP-1 cells. FcRn bound human IgG at pH ...