Importantly, RLRs cooperate in signaling crosstalk networks with Toll-like receptors and other factors to impart innate immunity and to modulate the adaptive immune response. RLR regulation occurs at a variety of levels ranging from autoregulation to ligand and cofactor interactions and posttranslational ...
Immune Signaling by RIG-I-like Receptors 来自 Elsevier 喜欢 0 阅读量: 118 作者: LM Gale 摘要: The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ...
Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk Nat. Immunol., 12 (2011), pp. 416-424 Google Scholar Loo and Gale, 2011 Y.M. Loo, M. Gale Jr. Immune signaling by RIG-I-like receptors Immunity, 34 (2011), pp...
Immune Signaling by RIG-I-like Receptors. IMMUNITY. 34, 680–692 (2011). CAS PubMed PubMed Central Google Scholar Yu, M. & Levine, S. J. Toll-Like Receptor 3, RIG-I-like Receptors and the NLRP3 Inflammasome: Key Modulators of Innate Immune Responses to Double-Stranded RNA Viruses. ...
RIG-I-like Receptors (RLRs), RIG-I, MDA5 and LGP2, play critical roles in innate immune defense against RNA viruses and are central to host immunity. RIG-I and MDA5 signal through CARDs to induce innate immune activation while LGP2 lacks these signaling domains but is thought to function...
Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), such as RIG-I, melanoma differentiation-associated gene 5 (MDA5), and virus-induced signaling adaptor (VISA), are intracellular molecules that sense diverse viral RNAs and trigger immune responses. In this study, we demonstrate that...
The RIG-I like receptors (RLRs) RIG-I and MDA5 are cytosolic RNA helicases best characterized as restriction factors for RNA viruses. However, evidence suggests RLRs participate in innate immune recognition of other pathogens, including DNA viruses. Kapo
ZAPS is an alternative splicing form of ZAP and promotes RIG-I oligomerization and ATPase activity, resulting in RIG-I activation. DDX60 is another cofactor involved in the viral RNA degradation via the RNA exosome. The DDX60 protein promotes RIG-I signaling in a cell-type specific manner. ...
By highlighting recent progress in these areas, we hope to convey a greater understanding of how viruses activate PRR signaling and how this interaction shapes the anti-viral immune response. 展开 关键词: pattern recognition receptor toll like receptor nod like receptor AIM2 like receptor RIG-I ...
Gale Jr. Immune signaling by RIG-I-like receptors Immunity, 34 (2011), pp. 680-692 View in ScopusGoogle Scholar Loo et al., 2008 Y.M. Loo, J. Fornek, N. Crochet, G. Bajwa, O. Perwitasari, L. Martinez-Sobrido, S. Akira, M.A. Gill, A. García-Sastre, M.G. Katze, M. ...