During virus infection, multiple immune signaling pathways are triggered, both within the host cell and bystander cells of an infected tissue. These pathways act in concert to mediate innate antiviral immunity and to initiate the inflammatory response against infection. The RIG-I-like receptor (RLR)...
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating interferon responses. ...
The RLG-I like receptor signaling pathway plays an important role in preventing the body from being infected by viruses. For this immune defense, the virus has some strategies to interfere with this process. After a virus infects cells, it often destroys the transduction of the RLR signaling ...
et al. Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer. Cell 170, 352–366.e13 (2017). CAS PubMed PubMed Central Google Scholar Gack, M. U. et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral ...
RIG-I like receptor signaling The RIG-I Like Receptors are cytoplasmic sensors that detectviral RNAPAMPsin a wide range of cell types (Figure 2a). The RLRs RIG-I andMDA5areISGsthat are transcribed during SARS-CoV infectionin vitro[23••]. MHV, anothercoronavirus, is recognized by MDA5...
RIG-I like receptor(retinoic acid-induced gene I) is a kind of RNA helicase in cytoplasm,which belongs to the pattern recognition receptor of innate immunity,which can bind the pathogenic correlation molecular formula and RNA ligand to identify non-own viral RNA,activate the RIG-I signaling path...
While LGP2, RIG-I and MAD5 have similar RNA-binding capacity, there are no N-terminal CARDs in LGP2 that are necessary for signaling transmission. Hence, LGP2 usually acts as a regulator of RIG-I and MDA5 [44]. LGP2 may repress RIG-I signaling through multiple mechanisms, such as in...
(RLRs)andtheiradaptorproteinMAVS,keycomponentsofthehostmachineryforsensingforeignRNA.Specifically,wesummarizerecentadvancesinunderstandinghowRLRsignalingisregulatedbyposttranslationalandposttranscriptionalmechanisms,microRNAs(miRNAs)andautophagy.Wefurtherdiscusshowvirusestargettheseregulatorymechanismsforimmuneevasion.Introduction...
The recognition of cytosolic DNA is more complicated than first anticipated. Several sensors have been identified that trigger different signaling pathways in a cell type-specific manner. Still, the general consensus is that another unknown cytosolic DNA-recognition system, independent of the TLRs and ...
RLRs-MAVS signaling pathway restricts KSHV lytic reactivation in BC-3 cells. a RNA was extracted from BC-3 cells expressing the indicated shRNAs and the target mRNA level was quantified by RT-qPCR. b Expression of KSHV viral genes in cells described in (a) was quantified by RT- qPCR. c ...