The present disclosure relates to, inter alia, RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).Arthur M. KRIEGAaron Jay MORRIS
Extracellular viral RNA can be recognized by transmembrane and endosomal Toll-like receptor 3 (TLR3) (Guillot et al., 2005; Schröder and Bowie, 2005), whereas intracellular viral RNA can be identified by the RIG-I-like receptors (RLRs), including RIG-I and MDA5, which can be induced ...
Toll‐like receptors (TLRs) and RIG‐I‐like receptors (RLRs) constitute distinct families of pattern‐recognition receptors that sense nucleic acids derived from viruses and trigger antiviral innate immune responses. TLR3, TLR7, and TLR9 are membrane proteins localized to the endosome that recognize...
Retinoic acid-inducible gene I(RIG-l)-like receptors(RLRs)are RNA sensor molecules that play essential roles in innate antiviral immunity.Among the three R... K Onomoto,K Onoguchi,M Yoneyama - 细胞与分子免疫学:英文版 被引量: 0发表: 2021年 Regulation of RIG-I-like receptor-mediated signal...
The role of the RIG-I like receptors in mediating CD8+ T cell immunity during virus infection West Nile virus (WNV) is a mosquito-borne Flavivirus that is a major cause of virus-induced encephalitis in the US. Upon virus infection, pattern recognition receptors (PRRs) recognize viral PAMPs ...
Peyman Nakhaei,Pierre Genin,Ahmet Civas, et al.RIG-I-like receptors:Sensing and responding to RNA virus infection.Seminars in Immunology.Nakhaei P, Genin P, Civas A, Hiscott J. RIG-I-like receptors: sensing and responding to RNA virus infection. Semin Immunol. 2009; 21:215-222. [Pub...
Therefore, we identified RIG-I and MDA5 as critical players in innate and adaptive immune responses against DENV, and targeting these receptors has the potential to decrease hemorrhagic fever in patients.Sprokholt, Joris K.Univ Amsterdam Acad Med Ctr Dept Expt Immunol Meibergdreef 9 NL-1105 ...
Pattern recognition receptors in the cytosol, such as RIG-I-like receptors (RLR) and Nod-like receptors (NLR), and membrane bound Toll like receptors (TLR) detect viral infection and initiate transcription of a cohort of antiviral genes, including interferon (IFN) and interferon stimulated genes...
In the absence of ubiquitin, the RIG-like receptors (RLRs), RIG-I and MDA5, bind their signaling partner, IPS1, via a direct interaction between the first RLR CARD domain (CARD1) and the...