The present disclosure relates to, inter alia, RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).Arthur M. KRIEG...
Toll‐like receptors (TLRs) and RIG‐I‐like receptors (RLRs) constitute distinct families of pattern‐recognition receptors that sense nucleic acids derived from viruses and trigger antiviral innate immune responses. TLR3, TLR7, and TLR9 are membrane proteins localized to the endosome that recognize...
Retinoic acid-inducible gene I(RIG-l)-like receptors(RLRs)are RNA sensor molecules that play essential roles in innate antiviral immunity.Among the three R... K Onomoto,K Onoguchi,M Yoneyama - 细胞与分子免疫学:英文版 被引量: 0发表: 2021年 Regulation of RIG-I-like receptor-mediated signal...
Upon sensing viral RNA, mammalian RIG-I-like receptors (RLRs) activate downstream signals using caspase activation and recruitment domains (CARDs), which ultimately promote transcriptional immune responses that have been well studied. In contrast, the downstream signaling mechanisms for invertebrate RLRs ...
Extracellular viral RNA can be recognized by transmembrane and endosomal Toll-like receptor 3 (TLR3) (Guillot et al., 2005; Schröder and Bowie, 2005), whereas intracellular viral RNA can be identified by the RIG-I-like receptors (RLRs), including RIG-I and MDA5, which can be induced ...
Therefore, we identified RIG-I and MDA5 as critical players in innate and adaptive immune responses against DENV, and targeting these receptors has the potential to decrease hemorrhagic fever in patients.Sprokholt, Joris K.Univ Amsterdam Acad Med Ctr Dept Expt Immunol Meibergdreef 9 NL-1105 ...
RIG-I-like receptors: sensing and responding to RNA virus infection. Semin. Immunol. 2009; 21:215-222. [PubMed: 19539500]P. Nakhaei, P. Genin, A. Civas, and J. Hiscott, "RIG-I-like receptors: sensing and responding to RNA virus infection," Seminars in Immunology, vol. 21, no. ...
In the absence of ubiquitin, the RIG-like receptors (RLRs), RIG-I and MDA5, bind their signaling partner, IPS1, via a direct interaction between the first RLR CARD domain (CARD1) and the...