UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract: The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunit…
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
All three RLR family receptors have a DExD/H box RNA helicase domain with ATPase activity. This domain along with the adjacent C-terminal domain is required for RNA binding. In addition, the C-terminal domains of RIG-I and LGP2 have been shown to act as repressor domains, ensuring that ...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
RIG-I-like receptors (RLRs) are viral RNA sensors and are essential for type I IFN induction. We herein summarize recent reports on RLR mutations in patients and MDA5 mutant mice, and discuss possible mechanisms by which aberrant activation of RLRs can cause autoimmunity....
This type of pattern-recognition receptor mainly includes Toll like receptors (TLRs), RIG-1 like receptors (RLRs), NOD-like receptors (NOD-like receptors, NLRs), Hin-200 family proteins and some DNA receptors. The RLRs in PRRs are a class of RNA helicases in the cytoplasm that recognize ...
The interferon (IFN) response is a powerful system that was evolutionarily acquired by vertebrates including mammals to protect against viral infection. The cytoplasmic RNA helicases, RIG-I-like receptors (RLRs), were discovered in 2004 as viral sensors that trigger the antiviral IFN response by re...
2015. Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity. Virol Sin 30:163-173. https://doi.org/10.1007/s12250-015-3604-5.J.S. Errett, M. Gale, Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity, Virol....
transductiontriggeredbyRIG-I-likereceptors(RLRs)andtheiradaptorproteinMAVS,key componentsofthehostmachineryforsensingforeignRNA.Specifically,wesummarizerecent advancesinunderstandinghowRLRsignalingisregulatedbyposttranslationaland posttranscriptionalmechanisms,microRNAs(miRNAs)andautophagy.Wefurtherdiscusshow ...