RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. ...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract:The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innateantiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role in ...
3.1RIG-I-like receptors in antiviral responses RIG-I-like receptors(RLRs) are cytoplasmic RNA sensors that initiate a type I interferon response upon RNAvirus infections. Currently, the RLR family contains three DExH/D box helicases, namely RIG-I,MDA5andLGP2. Upon ligand recognition, RIG-I ...
RIG-I-like receptorsViral infectionInnate immunityStress responseRetinoic acid-inducible gene I(RIG-l)-like receptors(RLRs)are RNA sensor molecules that play essential roles in innate antiviral immunity.Among the three RLRs encoded by the human genome,RIG-1 and melanoma differentiation-associated gene...
RIG-I-like receptors (RLRs) are intracellular PRRs that detect pathogenic RNA species generated during infection by RNA viruses, DNA viruses and some bacteria. The RLRs family comprises retinoic acid-inducible gene 1 (RIG-I, also called DDX58), melanoma differentiation-associated gene 5 (MDA5, ...
machineryforsensingforeignRNA.Specifically,wesummarizerecentadvancesinunderstandinghowRLRsignalingisregulatedbyposttranslationalandposttranscriptionalmechanisms,microRNAs(miRNAs)andautophagy.Wefurtherdiscusshowvirusestargettheseregulatorymechanismsforimmuneevasion.IntroductionMammaliancellspossesspattern-recognitionreceptors(PRRs)that...
RIG-I-like receptors (RLRs) constitute a family of cytoplasmic RNA helicases that are critical for host antiviral responses.
(TLRs), RIG-1 like receptors (RLRs), NOD-like receptors (NOD-like receptors, NLRs), Hin-200 family proteins and some DNA receptors. The RLRs in PRRs are a class of RNA helicases in the cytoplasm that recognize non-self viral RNA by binding their pathogen associated molecular pattern (...
InvivoGen provides an extensive list of tools to study RIG-I-like receptors RIG-I-like receptors (RLRs) are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I (retinoic-acid-inducible ...