UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract: The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunit…
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
RIG‐I‐like receptorsnon‐self RNASummary: Viral infection results in the generation of non‐self RNA species in the cells, which is recognized by retinoic acid inducible gene‐I‐like receptors (RLRs), and initiates innate antiviral responses, including the production of proinflammatory cytokines ...
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLR...
This type of pattern-recognition receptor mainly includes Toll like receptors (TLRs), RIG-1 like receptors (RLRs), NOD-like receptors (NOD-like receptors, NLRs), Hin-200 family proteins and some DNA receptors. The RLRs in PRRs are a class of RNA helicases in the cytoplasm that recognize ...
All three RLR family receptors have a DExD/H box RNA helicase domain with ATPase activity. This domain along with the adjacent C-terminal domain is required for RNA binding. In addition, the C-terminal domains of RIG-I and LGP2 have been shown to act as repressor domains, ensuring that ...
3.1.1RIG-I-like receptors (RLRs) TheRIG-I-like receptors(RLRs) are cytosolic proteins recognizing pathogen-derivednucleic acidspecies. In resting, these proteins are expressed at low levels in most cell types. However, upon stimulation by pathogen-derivednucleic acids, RLRs are induced to high ...
3.1RIG-I-like receptors in antiviral responses RIG-I-like receptors(RLRs) are cytoplasmic RNA sensors that initiate a type I interferon response upon RNAvirus infections. Currently, the RLR family contains three DExH/D box helicases, namely RIG-I,MDA5andLGP2. Upon ligand recognition, RIG-I ...