UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract: The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunit…
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR Neuroscience Pathways Proteases & Other Enzymes Pathways Signal Transduction Pathways Stem Cell Pathways Ubiquitin, Related Modifiers, & Pathways All three RLR family receptors have a DExD/H box RNA helicase domain...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
During RNA viral infection , RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and ...
在天然免疫反应中,宿主细胞的特异性受体能够识别病原相关分子模式(pathogen associated molecular patterns,PAMPs),从而诱导I型干扰素(IFNs)和炎性细胞因子产生。宿主细胞特异性受体被称为模式识别受体(pattern recognition receptors,PRRs),主要包括...
3.1RIG-I-like receptors in antiviral responses RIG-I-like receptors(RLRs) are cytoplasmic RNA sensors that initiate a type I interferon response upon RNAvirus infections. Currently, the RLR family contains three DExH/D box helicases, namely RIG-I,MDA5andLGP2. Upon ligand recognition, RIG-I ...
2. Yoneyama, M., and Fujita, T. (2008). Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity 29, 178–181.3. Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K.J., et al....
RIG-I-like receptor signaling pathway Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helica...