RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. ...
2024年1月16日,来自美国康涅狄格大学健康中心的Penghua Wang团队在Nat Communications杂志上发表题为“UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors”的研究性论文。该研究探索了UBR5在...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RLR家族的另一个成员LGP2缺乏CARD结构域。体外研究表明LGP2是RIG-I和MDA5信号通路的负调控因子。LGP2能分离dsRNA，抑制RIG-I构象变化。然而，LGP2-/-小鼠的体内研究表明，LGP2正调控RIG-I和MDA5介导的I型IFN的产生。然而，在合成RNA刺激后，LGP2对于I型IFN的产生是可有可无的。RLRs家族的c端调控域(C-termin...
PRRs广泛存在于细胞的各处,包括Toll样受体(TLRs,Toll-like receptor)、Nod样受体(NLRs,Nucleotide-binding and oligomerization domain (NOD)-like receptors)、RIG-I样受体(RLRs,RIG-I-like receptors)等一系列不同受体家族。RLR家族主要分布在细胞液中,是识...
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or bacterial infection and induce host innate immune responses. The RLRs family comprises retinoic acid-inducible gene 1 (RIG-I), melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics...
RIG-I样受体(RIG-I like receptors,RLRs) NOD样受体(NOD-like receptors,NLRs) C型凝集素样受体(C-type lectin receptors,CLRs) 胞浆DNA受体(cytosolic DNA receptors,CDRs) RLRs作为细胞质中重要的PRRs,能够识别双链RNA病毒,是抗病毒天然免疫与适应性免疫非常重要的组成部分。其家族有3个成员: ...
2024年1月16日,来自美国康涅狄格大学健康中心的Penghua Wang团队在Nat Communications杂志上发表题为“UBR5 promotes antiviral immunity by disengaging the tranional brake on RIG-I like receptors”的研究性论文。该研究探索了UBR5在抗病毒免疫中的作用。研究人员发现UBR5可以解除对RIG-I类受体的转录抑制,从而促进...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract:The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innateantiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role in...
The cytoplasmic RNA helicases, RIG-I-like receptors (RLRs), were discovered in 2004 as viral sensors that trigger the antiviral IFN response by recognizing the nonself signatures of viral RNAs. The mechanisms underlying the recognition of viral RNAs and signal transduction leading to the production...