Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an anti
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
RIG-I-like receptors (RLRs) are a family of ubiquitously expressed PRRs that detect “non-self” viral RNAs in the cytoplasm. From:Cytokine & Growth Factor Reviews,2014 Also in subject areas: Biochemistry, Genetics and Molecular Biology
RIG-I like receptors (RLRs) RIG-I (retinoic acid-inducible gene I) and MDA5 (melanoma differentiation-associated gene-5) are closely related DExD/H-box helicase family proteins. They consist of an N-terminal tandem caspase activation and recruitment domain (CARD) fused to a DExD/H-box hel...
2024年1月16日,来自美国康涅狄格大学健康中心的Penghua Wang团队在Nat Communications杂志上发表题为“UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors”的研究性论文。该研究探索了UBR5在...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract: The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role ...
Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR Neuroscience Pathways Proteases & Other Enzymes Pathways Signal Transduction Pathways Stem Cell Pathways Ubiquitin, Related Modifiers, & Pathways All three RLR family receptors have a DExD/H box RNA helicase domain...
宿主细胞特异性受体被称为模式识别受体(pattern recognition receptors,PRRs),主要包括Toll样受体(toll-like receptors,TLRs)、RIG-I样受体(RIG-I like receptors,RLRs)、NOD样受体(NOD-like receptors,NLRs)、C型凝集素样受体(C-type lectin...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
RIG-I-like receptors (RLRs) are intracellular PRRs that detect pathogenic RNA species generated during infection by RNA viruses, DNA viruses and some bacteria. The RLRs family comprises retinoic acid-inducible gene 1 (RIG-I, also called DDX58), melanoma differentiation-associated gene 5 (MDA5, ...