2024年1月16日,来自美国康涅狄格大学健康中心的Penghua Wang团队在Nat Communications杂志上发表题为“UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors”的研究性论文。该研究探索了UBR5在...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract: The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role ...
Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR Neuroscience Pathways Proteases & Other Enzymes Pathways Signal Transduction Pathways Stem Cell Pathways Ubiquitin, Related Modifiers, & Pathways All three RLR family receptors have a DExD/H box RNA helicase domain...
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
宿主细胞特异性受体被称为模式识别受体(pattern recognition receptors,PRRs),主要包括Toll样受体(toll-like receptors,TLRs)、RIG-I样受体(RIG-I like receptors,RLRs)、NOD样受体(NOD-like receptors,NLRs)、C型凝集素样受体(C-type lectin...
RIG-I-like receptors (RLRs) are nucleic acid sensors that activate antiviral innate immune response. These molecules recognize diverse non-self RNA substrates and are antagonized by several viral inhibitors. We performed an evolutionary analysis of RLR genes (RIG-I, MDA5, and LGP2) in mammals....
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
RLRs定位在细胞质中。病毒感染或I型干扰素刺激可显著增强RLRs的表达。RIG-I缺陷细胞，如cdc和小鼠成纤维细胞，不能有效地产生I型ifn和炎症细胞因子，以应对许多RNA病毒。这些RNA病毒包括仙台病毒(SeV)、水泡性口炎病毒(VSV)、日本脑炎病毒(JEV)、新城疫病毒(NDV)、流感病毒等。相反，MDA5缺陷细胞对上述RNA病毒反应...
RIG-I样受体(RIG-I like receptors,RLRs) NOD样受体(NOD-like receptors,NLRs) C型凝集素样受体(C-type lectin receptors,CLRs) 胞浆DNA受体(cytosolic DNA receptors,CDRs) RLRs作为细胞质中重要的PRRs,能够识别双链RNA病毒,是抗病毒天然免疫与适应性免疫非常重要的组成部分。其家族有3个成员: ...