RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. ...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
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Nat Communications|UBR5通过解除RIG-I样受体的转录制动来促进抗病毒免疫 2024年1月16日,来自美国康涅狄格大学健康中心的Penghua Wang团队在Nat Communications杂志上发表题为“UBR5 promotes antiviral immunity by disengaging the tranional brake on RIG-I like receptors”的研究性论文。该研究探索了UBR5在抗病毒免疫...
3.1RIG-I-like receptors in antiviral responses RIG-I-like receptors(RLRs) are cytoplasmic RNA sensors that initiate a type I interferon response upon RNAvirus infections. Currently, the RLR family contains three DExH/D box helicases, namely RIG-I,MDA5andLGP2. Upon ligand recognition, RIG-I ...
RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol Rev. 2011;243:91–8. : 10.1111/j.1600-065X.2011.01052.x . View ArticleKiyohiro Takahasi,Takashi Fujita.RIG‐I‐like receptors: cytoplasmic sensors for non‐self RNA.Immunological Reviews. 2011...
(IFNs)andproinflammatorycytokines.Adelicateregulationofthesignalingpathwaysthatleadtocytokineproductionisneededtoensureeffectiveclearanceofthevirus,whilepreventingtissuedamagecausedbyexcessivecytokinerelease.Here,wefocusonthemechanismsthatmodulatethesignaltransductiontriggeredbyRIG-I-likereceptors(RLRs)andtheiradaptorprotein...
RIG-I-like receptors (RLRs) are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I (retinoic-acid-inducible protein 1) and MDA5 (melanoma-differentiation-associated gene 5) sense double-str...
Emerging and re-emerging viruses pose a significant public health challenge around the world, among which RNA viruses are the cause of many major outbreaks of infectious diseases. As one of the early lines of defense in the human immune system, RIG-I-like receptors (...
RIG-I like receptors and autoimmune diseases RIG-I–like receptors (RLRs) are known as viral RNA sensors that trigger the antiviral interferon (IFN) response by the recognition of the nonself signatur... A Schlichting 被引量: 0发表: 0年 Immune Signaling by RIG-I-like Receptors The RIG-I...