Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract: The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunit…
Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions Neuropoietin Signaling Pathways NOD-like Receptor Signaling Pathways Oncostatin M Signaling Pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ...
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
During RNA viral infection , RIG-I-like receptors (RLRs) recognize the intracellular pathogenic RNA species derived from viral replication and activate antiviral innate immune response by stimulating type 1 interferon expression. Three RLR members, namely, RIG-I, MDA5, and LGP2 are homologous and ...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
3.1RIG-I-like receptors in antiviral responses RIG-I-like receptors(RLRs) are cytoplasmic RNA sensors that initiate a type I interferon response upon RNAvirus infections. Currently, the RLR family contains three DExH/D box helicases, namely RIG-I,MDA5andLGP2. Upon ligand recognition, RIG-I ...
Dixit E, Kagan JC (2013) Intracellular pathogen detection by RIG-I-like receptors . Adv Immunol 117 : 99–125doi: 10.1016/B978-0-12-410524-9.00004-9Dixit E, Kagan JC (2013) Intracellular pathogen detection by RIG-I-Like receptors. Adv Immunol 117:99–125. : 10.1016/B978-0-...
宿主细胞特异性受体被称为模式识别受体(pattern recognition receptors,PRRs),主要包括Toll样受体(toll-like receptors,TLRs)、RIG-I样受体(RIG-I like receptors,RLRs)、NOD样受体(NOD-like receptors,NLRs)、C型凝集素样受体(C-type lectin...
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