Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
3.1RIG-I-like receptors in antiviral responses RIG-I-like receptors(RLRs) are cytoplasmic RNA sensors that initiate a type I interferon response upon RNAvirus infections. Currently, the RLR family contains three DExH/D box helicases, namely RIG-I,MDA5andLGP2. Upon ligand recognition, RIG-I ...
RIG-I-like receptors (RLRs) are viral RNA sensors and are essential for type I IFN induction. We herein summarize recent reports on RLR mutations in patients and MDA5 mutant mice, and discuss possible mechanisms by which aberrant activation of RLRs can cause autoimmunity....
Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions Neuropoietin Signaling Pathways NOD-like Receptor Signaling Pathways Oncostatin M Signaling Pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
This type of pattern-recognition receptor mainly includes Toll like receptors (TLRs), RIG-1 like receptors (RLRs), NOD-like receptors (NOD-like receptors, NLRs), Hin-200 family proteins and some DNA receptors. The RLRs in PRRs are a class of RNA helicases in the cytoplasm that recognize ...
宿主细胞特异性受体被称为模式识别受体(pattern recognition receptors,PRRs),主要包括Toll样受体(toll-like receptors,TLRs)、RIG-I样受体(RIG-I like receptors,RLRs)、NOD样受体(NOD-like receptors,NLRs)、C型凝集素样受体(C-type lectin...
(2020) RIG-I-like receptors: their regulation and roles in RNA sensing. Nat Rev Immunol. 2. Jang, M.A., Kim, E.K., Now, H., Nguyen, N.T.H., Kim, W.J., Yoo, J.Y., Lee, J., Jeong, Y.M., Kim...
在天然免疫反应中,宿主细胞的特异性受体能够识别病原相关分子模式(pathogen associated molecular patterns,PAMPs),从而诱导I型干扰素(IFNs)和炎性细胞因子产生。宿主细胞特异性受体被称为模式识别受体(pattern recognition receptors,PRRs),主要包括: Toll样受体(toll-like receptors,TLRs)...