Key structural domains involved in signaling are shown. The RLRs consist of CARD (caspase activation and recruitment domain); ATPase containing DEAD box helicase (DEAD helicase); and a C-terminal domain (CTD) that in RIG-I and LGP2 but not MDA5 encodes a repressor domain (RD) involved in...
When retinoic acid-inducible gene 1 protein (RIG-I)-like receptors sense viral dsRNA in the cytosol, RIG-I and melanoma differentiation-associated gene 5 (MDA5) are recruited to the mitochondria to interact with mitochondrial antiviral signaling protein (MAVS) and initiate antiviral immune responses...
The role of PRRs including Toll-like Receptors (TLRs) and RIG-I-like receptors (RLRs) in the pathogenesis of SARS-CoV is the focus of this dissertation.Totura, AllisonDissertations & Theses GradworksTOTURA A. SARS coronavirus antagonizes innate immune signaling initiated by RIG-I but is ...
Recognition of the virus by innate immune receptors in a multitude of cell types activates intricate signaling networks, functioning to restrict viral replication. Downstream effector mechanisms include activation of innate immune cells and, induction and regulation of adaptive immunity. However, ...
Notably, influenza virus employs its nonstructural protein 1 (NS1) to subvert RIG-I ubiquitination-dependent signaling by binding to and inhibiting TRIM25 (Gack et al., 2009). Furthermore, we have recently shown that Ser-Thr phosphorylation of the RIG-I tandem CARD keeps RIG-I inactive and ...
Ubiquitination in PRR signaling Innate immune recognition is based on PAMP detection by several families of PRRs, including toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), and cytosolic DNA sensors12. TLRs are a family of ...
been described as having inhibitory effects on proinflammatory signaling. NLRX1 can inhibit the type I interferon pathway by interfering with the adaptor MAVS–RNA helicase RIG-I pathway and the NF-κB pathway via the signaling adaptor TRAF6 (refs. 19–21), and NLRC5 inhibits type I interferon...
RIG-I-likereceptors(RLRs)arecytoplasmicsensorsforviralRNAthatelicitantiviralinnateimmune responses.RLRsignalingculminatesintheactivationoftheproteinkinaseTBK1,whichmediates phosphorylationandnucleartranslocationofIRF3thatregulatesexpressionoftypeIinterferongenes. Here,wefoundthatNucleoporin93(Nup93),componentsofnuclearpore...
RNA recognition and signal transduction by RIG-I-like receptors Summary: Viral infection is detected by cellular sensor molecules as foreign nucleic acids and initiates innate antiviral responses, including the activat... M Yoneyama,T Fujita - 《Immunological Reviews》 被引量: 1362发表: 2010年 Depe...
Toll-like receptors (TLRs) are evolutionary conserved, germ-line encoded molecules that express an ectodomain with leucine-rich regions, a single transmembrane domain, and a cytoplasmic region that contains the Toll-IL-1R resistance (TIR) signaling domain. TLRs recognize bacterial and viral pathogen-...