RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. ...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
Abstract:The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innateantiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role in antiviral immunity is elusive. Here, we unveil that insulin-responsive GLUT4 inhibits R...
RIG-I-like receptors (RLRs) are a family of ubiquitously expressed PRRs that detect “non-self” viral RNAs in the cytoplasm. From:Cytokine & Growth Factor Reviews,2014 Add to Mendeley Also in subject areas: Biochemistry, Genetics and Molecular Biology ...
RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol Rev. 2011;243:91–8. : 10.1111/j.1600-065X.2011.01052.x . View ArticleKiyohiro Takahasi,Takashi Fujita.RIG‐I‐like receptors: cytoplasmic sensors for non‐self RNA.Immunological Reviews. 2011...
RIG-I-like receptors (RLRs) are intracellular PRRs that detect pathogenic RNA species generated during infection by RNA viruses, DNA viruses and some bacteria. The RLRs family comprises retinoic acid-inducible gene 1 (RIG-I, also called DDX58), melanoma differentiation-associated gene 5 (MDA5, ...
(IFNs)andproinflammatorycytokines.Adelicateregulationofthesignalingpathwaysthatleadtocytokineproductionisneededtoensureeffectiveclearanceofthevirus,whilepreventingtissuedamagecausedbyexcessivecytokinerelease.Here,wefocusonthemechanismsthatmodulatethesignaltransductiontriggeredbyRIG-I-likereceptors(RLRs)andtheiradaptorprotein...
RIG-I-like receptors (RLRs) are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I (retinoic-acid-inducible protein 1) and MDA5 (melanoma-differentiation-associated gene 5) sense double-str...
Negative-strand RNA virus Genome segmentation RIG-I-like receptors Panhandle Viral countermeasures 1. Introduction Viruses with a single-stranded (ss) RNA genome of negative polarity (negative-strand RNA viruses, NSVs) are responsible for a wide range of diseases. Members of the NSV group cause ...
Emerging and re-emerging viruses pose a significant public health challenge around the world, among which RNA viruses are the cause of many major outbreaks of infectious diseases. As one of the early lines of defense in the human immune system, RIG-I-like receptors (...