UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Abstract: The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role ...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. Latest...
RIG‐I‐like receptorsnon‐self RNASummary: Viral infection results in the generation of non‐self RNA species in the cells, which is recognized by retinoic acid inducible gene‐I‐like receptors (RLRs), and initiates innate antiviral responses, including the production of proinflammatory cytokines ...
All three RLR family receptors have a DExD/H box RNA helicase domain with ATPase activity. This domain along with the adjacent C-terminal domain is required for RNA binding. In addition, the C-terminal domains of RIG-I and LGP2 have been shown to act as repressor domains, ensuring that ...
RIG-I-like receptors(RLRs)are a family of three cytoplasmic RNA helicases that are critical for the effective immune response against viruses through the sensing of cytoplasmic RNA. RIG-I(retinoic-acid-inducible protein 1) andMDA5(melanoma-differentiation-associated gene 5) sense double-stranded RN...
The transmission of this signal in cells requires a class of pattern-recognition receptors (PRRs) to specifically recognize the pathogen associated molecular pattern (PAMP) of viral expression. This type of pattern-recognition receptor mainly includes Toll like receptors (TLRs), RIG-1 like receptors ...
RIG-I-like receptors(RLRs) utilize a specialized, multi-domain architecture to detect and respond to invasion by a diverse set of viruses. Structural similarities among these receptors provide a general mechanism for double strandRNArecognition andsignal transduction. However, eachRLRhas developed unique...
Dixit E, Kagan JC (2013) Intracellular pathogen detection by RIG-I-like receptors . Adv Immunol 117 : 99–125doi: 10.1016/B978-0-12-410524-9.00004-9Dixit E, Kagan JC (2013) Intracellular pathogen detection by RIG-I-Like receptors. Adv Immunol 117:99–125. : 10.1016/B978-0-...
transductiontriggeredbyRIG-I-likereceptors(RLRs)andtheiradaptorproteinMAVS,key componentsofthehostmachineryforsensingforeignRNA.Specifically,wesummarizerecent advancesinunderstandinghowRLRsignalingisregulatedbyposttranslationaland posttranscriptionalmechanisms,microRNAs(miRNAs)andautophagy.Wefurtherdiscusshow ...