This study reveals a novel mechanism of interplay between the NLR and RLR pathways. CAS PubMed PubMed Central Google Scholar Wang, P. et al. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat. Immunol. 11, 912–919 (2010). CAS PubMed PubMed Central ...
RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway RIPAIRF3天生的免疫天生的有免疫力的反应是主人防卫的第一根线消除病毒的感染.在 cytosol 的模式识别受体例如 RIG-I-like 受体( RLR )和像点头的受体( NLR ),并且如同受体( TLR )检测病毒的感染并且开始抗...
Interferons are important components of the host innate immune response. Type I IFNs (IFN-α, -β, -ε and -Ω) engage IFN-α/β receptor (IFNAR) and activate the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to the expression of interferon-s...
RLRs are critical for immune defense against a range of RNA viruses4including flaviviruses that are recognized through both RIG-I and MDA55, yet the specific contributions of each receptor to the innate immune response are unclear. West Nile Virus (WNV) is a neurotropic flavivirus that is the...
RIG-I-Like Receptor Ligands RLRs are a family of DExD/H boxRNA helicasesthat recognize viral ds or uncapped RNAs within the cytosol of infected cells. They can initiate and modulateantiviral immunity[35]. To date, three RLR members have been identified: RIG-I (retinoic acid-inducible gene ...
RIG-I-likereceptorregulationinvirusinfectionandimmunityYingKaiChanandMichaelaUGackDepartmentofMicrobiologyandImmunobiology,HarvardMedicalSchool,Boston,MA02115,USAAbstractMammaliancellshavetheintrinsiccapacitytodetectviralpathogensandtoinitiateanantiviralresponsethatischaracterizedbytheinductionofinterferons(IFNs)andproinflammator...
Viral dsRNA is also recognized byToll-Like receptor 3 (TLR3)which is expressed on the cell surface membrane or endosomes. Recognition of dsRNA by RIG-I/MDA-5 or TLR3 is cell-type dependent. Studies of RIG-I- and MDA-5-deficient mice have revealed that conventional dendritic cells (DCs)...
RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immu... type I interferonRIG-IMDA5SARS-CoV-2CoronavirusRIG-I-like receptors (RLR), RIG-I and MDA5, are cytoplasmic viral RNA sensors that ...
The RLG-I like receptor signaling pathway plays an important role in preventing the body from being infected by viruses. For this immune defense, the virus has some strategies to interfere with this process. After a virus infects cells, it often destroys the transduction of the RLR signaling ...
The RIG-I-like receptor (RLR) family of PRRs is a group of cytosolic RNA helicases capable of discriminating self vs. nonself RNA. To date, three RLR members have been identified, retinoic acid-inducible gene-I (RIG-I; DDX58), melanoma-differentiation-associated gene 5 (MDA5), and labo...