TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions Toll-Like Receptor Signaling Pathways Type I Interferon Signaling Pathways Type II Interferon Signaling Pathways Type III Interferon Signaling Pathways VEGF - VEGF R2 Signaling Pathways ...
RIG-I-like receptorMolecules recognizedNOD-like receptor
RIG-I-Like Receptor Ligands RLRs are a family of DExD/H boxRNA helicasesthat recognize viral ds or uncapped RNAs within the cytosol of infected cells. They can initiate and modulateantiviral immunity[35]. To date, three RLR members have been identified: RIG-I (retinoic acid-inducible gene ...
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating interferon responses. Andrew G. Harrison ...
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection. Nat. Commun. 9, 4841 (2018). This manuscript reports the activation of RIG-I in KSHV-infected cells due to virus-induced defects in the normal post-transcriptional processing of cellular ...
最新研究表明,LGP2可通过两种机制调节CD8+T细胞凋亡与抗凋亡:(1)激活T细胞受体(T cell receptor,TCR),促进LGP2过表达,而过表达的LGP2通过与细胞表面受体Fas(factor related apoptosis,或称CD95/APO-1)相互作用,延缓CD8+T细胞的凋亡进程(...
Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I 热度: Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France ...
TOLL-LIKE RECEPTOR-3E3 UBIQUITINLIGASEDOUBLE-STRANDED-RNAIFN-BETA PROMOTERINDUCIBLE GENE-IThe RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic ...
The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short... ML Goulet,D Olagnier,Z Xu,... - 《Plos Pathogens》 被引量: 104发表: 2013年 FLN29 deficiency reveals its negative regulatory role in...
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection. Nat Commun. 2018;9(1):4841. 40. Ranoa DR, Parekh AD, Pitroda SP, Huang X, Darga T, Wong AC, et al. Cancer therapies activate RIG-I-like receptor pathway through endogenous non...