RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection. Nat. Commun. 9, 4841 (2018). This manuscript reports the activation of RIG-I in KSHV-infected cells due to virus-induced defects in the normal post-transcriptional processing of cellular ...
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating interferon responses. ...
RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway. Protein Cell 2017; 8 (3): 165-8.Chattopadhyay, S., and Sen, G. C. (2016). RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway. Protein Cell 8...
RIG-I-Like Receptor Ligands RLRs are a family of DExD/H boxRNA helicasesthat recognize viral ds or uncapped RNAs within the cytosol of infected cells. They can initiate and modulateantiviral immunity[35]. To date, three RLR members have been identified: RIG-I (retinoic acid-inducible gene ...
日本学者于2004年在研究RNA病毒引起的先天性抗病毒免疫时再次克隆到RIG-I,此后,RIG-I作为RLR(RIG-I like receptor)的先证分子得到广泛而深入的研究。RIG-I识别胞内病毒复制的中间产物5’ppp-dsRNA后发生变构,暴露N端CARD结构并多聚...
RIG-I-likereceptorregulationinvirusinfectionandimmunityRIG-I样受体调节病毒感染和免疫 系统标签: rigvirusinfectionregulationreceptorimmunity RIG-I-likereceptorregulationinvirusinfectionandimmunityYingKaiChanandMichaelaUGackDepartmentofMicrobiologyandImmunobiology,HarvardMedicalSchool,Boston,MA02115,USAAbstractMammaliancells...
RIG-I (retinoic acid-inducible gene I) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded (in humans) by the DDX58 gene. RIG-I is part of the RIG-I-like receptor family, which also includes MDA5 and LGP2, and functions as a pattern recognition receptor that is a ...
RIG-I receptor regulation of T cell immunity during virus infection (P4361) West Nile Virus (WNV) is an RNA virus that is the leading cause of mosquito-borne encephalitis in the United States. Recently, we demonstrated that MAVS, the central adaptor molecule of the RIG-I like receptor (RLR...
最新研究表明,LGP2可通过两种机制调节CD8+T细胞凋亡与抗凋亡:(1)激活T细胞受体(T cell receptor,TCR),促进LGP2过表达,而过表达的LGP2通过与细胞表面受体Fas(factor related apoptosis,或称CD95/APO-1)相互作用,延缓CD8+T细胞的凋亡进程(...
HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1. RIG-I like receptors (RLRs) recognize cytosolic viral RNA and initiate innate immunity; they increase the production of type I interferon (IFN) and the tr...