TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions Toll-Like Receptor Signaling Pathways Type I Interferon Signaling Pathways Type II Interferon Signaling Pathways Type III Interferon Signaling Pathways VEGF - VEGF R2 Signaling Pathways ...
近日,来自美国克利夫兰医学中心的Michaela U. Gack团队和德国乌尔姆大学医学中心的Konstantin M.J. Sparrer团队在Cell杂志上合作发表了一篇题为Actin cytoskeleton remodeling primes RIG-I-like receptor activation的文章,他们证明PP1α/γ对RLRs的特异性...
英文名称 Human retinoic acid inducible gene/RIG-like receptor, RLR-9 Elisa Kit 规格 96T/48T 包装 盒装液体 贮藏 2-8℃,避光防潮保存 运输方式 顺丰快递 使用方法 竞争法、夹心法、间接法 样本类型 血清,血浆,尿液,组织匀浆等 用途范围 仅用于科研 特点 特异性强,重复性好 运输 免费包邮 ...
维甲酸诱导基因I(Retinoic acid inducible gene I,RIG-I)最初是上世纪末上海市血液学研究所陈竺院士团队在全反式维甲酸(ATRA)诱导急性早幼粒细胞白血病(APL)分化中发现的一系列诱导上调的基因之一。日本学者于2004年在研究RNA病毒引起...
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating interferon responses. Andrew G. Harrison ...
RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway. Protein Cell 2017; 8 (3): 165-8.Chattopadhyay, S., & Sen, G. C. (2017). RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway. Protein and Cell...
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection. Nat. Commun. 9, 4841 (2018). This manuscript reports the activation of RIG-I in KSHV-infected cells due to virus-induced defects in the normal post-transcriptional processing of cellular ...
PRRs广泛存在于细胞的各处,包括Toll样受体(TLRs,Toll-like receptor)、Nod样受体(NLRs,Nucleotide-binding and oligomerization domain (NOD)-like receptors)、RIG-I样受体(RLRs,RIG-I-like receptors)等一系列不同受体家族。RLR家族主要分布在细胞液中,是识别病原体双链RNA的关键受体,能够防御多种病原体,比如包括...
视黄酸诱导基因1(retinoicacidinduciblegene-1,RIG-1)产物和黑色素瘤分化相关分子(MDA-5)是胞质溶胶中识别病毒双链RNA(dsRNA)的感知元件(sensor),也是RIG-1相关受体(RIG--1—likereceptor,RLR)家族中的主要成员。RLR和NLR结构上的相似之处,是都带有效应结构域CARD。elisa试剂盒 ...
This challenging task is taken on by the homologous cytosolic DExD/H-box family helicases RIG-I and MDA5, which control the innate immune response to most RNA viruses. This review focuses on the molecular basis for RIG-I like receptor (RLR) activation by synthetic and natural ligands and ...