RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection. Nat. Commun. 9, 4841 (2018). This manuscript reports the activation of RIG-I in KSHV-infected cells due to virus-induced defects in the normal post-transcriptional processing of cellular ...
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating interferon responses. ...
RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway. Protein & cell. 2017;8:165-8.Chattopadhyay, S., & Sen, G. C. (2017). RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway. Protein and Cell, 8...
PRRs广泛存在于细胞的各处,包括Toll样受体(TLRs,Toll-like receptor)、Nod样受体(NLRs,Nucleotide-binding and oligomerization domain (NOD)-like receptors)、RIG-I样受体(RLRs,RIG-I-like receptors)等一系列不同受体家族。RLR家族主要分布在细胞液中,是识...
RIG-I-Like Receptor Ligands RLRs are a family of DExD/H boxRNA helicasesthat recognize viral ds or uncapped RNAs within the cytosol of infected cells. They can initiate and modulateantiviral immunity[35]. To date, three RLR members have been identified: RIG-I (retinoic acid-inducible gene ...
日本学者于2004年在研究RNA病毒引起的先天性抗病毒免疫时再次克隆到RIG-I,此后,RIG-I作为RLR(RIG-I like receptor)的先证分子得到广泛而深入的研究。RIG-I识别胞内病毒复制的中间产物5’ppp-dsRNA后发生变构,暴露N端CARD结构并多聚...
like receptors (TLRs), cyclic GMP-AMP synthase (cGAS)-stimulator of interferon response CGAMP interactor (STING) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2), leading to the increased assembly of an innate immune complex termed inflammasome that contains Nod-like receptor ...
RIG-I-likereceptorregulationinvirusinfectionandimmunityYingKaiChanandMichaelaUGackDepartmentofMicrobiologyandImmunobiology,HarvardMedicalSchool,Boston,MA02115,USAAbstractMammaliancellshavetheintrinsiccapacitytodetectviralpathogensandtoinitiateanantiviralresponsethatischaracterizedbytheinductionofinterferons(IFNs)andproinflammator...
英文名称:RIG-I-like Receptor品牌厂商性质产地货期 MedChemExpress (MCE) 生产商 美国 现货在线咨询 询底价 AI问答 配套的仪器设备? 可以搭配的相关耗材试剂?产品介绍 更多详情参考:https://www.medchemexpress.cn/proteins/rig-i-like-receptor.html RIG-I 样受体 (RIG-I-like Receptor) | 重组蛋白 | ...
最新研究表明,LGP2可通过两种机制调节CD8+ T细胞凋亡与抗凋亡:(1)激活T细胞受体(T cell receptor,TCR),促进LGP2过表达,而过表达的LGP2通过与细胞表面受体Fas(factor related apoptosis,或称CD95/APO-1)相互作用,延缓CD8+ T细胞的凋亡进程(图2:I),从而维持CD8+ T细胞的正常功能。(2)机体受到抗原刺激后,LGP2...