Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
Autoimmune diseaseSLEAGSSMSRIG-I–like receptors (RLRs) are known as viral RNA sensors that trigger the antiviral interferon (IFN) response by the recognition of the nonself signatures in viral RNAs, including 5' triphosphate stdoi:10.1007/978-4-431-56068-5_39Hiroki Kato...
RIG-I-like receptors and autoimmune diseases Type I interferon (IFN) plays an essential role in antiviral innate immune responses and also in adaptive immune responses. Defects in the production of IFN markedly increase susceptibility to viral invasion and attenuate the acquired im... H Kato,T Fu...
In higher vertebrates, recognition of the non-self signature of invading viruses by genome-encoded pattern recognition receptors initiates antiviral innate immunity. Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) detect viral RNA as a non-self pattern in the cytoplasm and activate dow...
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ligands or processed self RNA in the cytoplasm to trigger innate immunity and inflammation and to ...
The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role in antiviral immunity is elusive. Here, we unvei
Toll-like receptors (TLRs) and retinoic acid-inducible gene I- (RIG-I-) like receptors (RLRs) are crucial pattern recognition receptors (PRRs) that play essential roles in recognizing and clearing pathogens, including resisting flavivirus. In the present review, we provide a significant reference...
When invaded by a virus, a host produces a rapid innate immune response initiated by pathogen pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG- I) like receptors (RLRs), the cyclic GMP-AMP (cGAMP) synthase (cGAS), and ...
Comparative analysis of viral RNA signatures on different RIG-I-like receptors. Elife. 2016;5:e11275. Article PubMed PubMed Central Google Scholar Baum A, Sachidanandam R, García-Sastre A. Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation ...
RIG-I-like Receptors (RLRs) are one family of PRR proteins comprised of three homologous SF2 helicases—RIG-I, MDA-5 and LGP2—that detect and respond to non-self dsRNA [1–3]. From:Current Opinion in Structural Biology,2014 Also in subject areas: ...