Function of RIG-I-like receptors in antiviral innate immunity. J. Biol. Chem. 282 (21), 15315-15318.Fujita T (2007) Function of RIG-I-like receptors in antiviral innate immunity - YoneyamaYoneyama M , Fujita T ( 2007 ) Function of RIG-I-like receptors in antiviral innate immunity . ...
Function of RIG-I-like Receptors in Antiviral Innate Immunity. The article describes the function of retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) in antiviral innate immunity. The RLR are subsets of mole... Yoneyama,Mitsutoshi,Fujita,... - 《Journal of Biological Chemistry》 ...
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs ...
RIG-I-Like Receptors (RLRs) RIG-I, MDA5, and LGP2, are vital pathogen recognition receptors in the defense against RNA viruses. West Nile Virus (WNV) infections continue to grow in the US. Here, we use a systems biology approach to define the contributions of each RLR in the innate im...
因此,在正常情况下机体自身来源的 RNA 均不会在胞浆中激活 RIG-I 信号。但是,机体内仍存在少量 5’端磷酸化的自身 RNA,这些自身 RNA 如 何实现逃避 RIG-I 识别的机制还不十分清楚(Yoneyama M 等,Function of RIG-Ilike receptors in antiviral innate immunity.J Biol Chem.2007,282:15315-15318) 。此外,...
RIG-I-like receptors (RLRs) are intracellular PRRs that detect pathogenic RNA species generated during infection by RNA viruses, DNA viruses and some bacteria. The RLRs family comprises retinoic acid-inducible gene 1 (RIG-I, also called DDX58), melanoma differentiation-associated gene 5 (MDA5, ...
PRRs广泛存在于细胞的各处,包括Toll样受体(TLRs,Toll-like receptor)、Nod样受体(NLRs,Nucleotide-binding and oligomerization domain (NOD)-like receptors)、RIG-I样受体(RLRs,RIG-I-like receptors)等一系列不同受体家族。RLR家族主要分布在细胞液中,是识...
我们首次发现了ZNF205在RIG-I介导的抗病毒信号通路中的正调控作用。然而 关于ZNF205调控RIG-I的精细机制尚需要更深入的探索。 关键词:ZNF205;RIG-I;泛素化;RLR抗病毒信号通路 I Abstract PatternRecognitionReceptors(PRRs)areabletodirectlyrecognizepathogens ...
2024年1月16日,来自美国康涅狄格大学健康中心的Penghua Wang团队在Nat Communications杂志上发表题为“UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors”的研究性论文。该研究探索了UBR5在抗病毒免疫中的作用。研究人员发现UBR5可以解除对RIG-I类受体的转录抑制,从而...
RIG-I-like receptors (retinoic acid-inducible gene I-like receptors, RLRs) are a family of molecules that are expressed inside cells in order to sense viruses. They recognise double-stranded RNA molecules that are produced by certain viruses and can induce antiviral immune responses. ...