参考文献 [1] Leonard, W.J. & Wan, C.K. IL-21 Signaling in Immunity. F1000Res 5 (2016). 百奥动物还在持续开发一系列细胞因子人源化小鼠模型,助力全球新药研发!点击“
IL-21R信号通路通过降低IL-2的表达间接抑制Treg的免疫抑制功能。IL-21可抑制幼稚CD4+T细胞中肿瘤介导的FOXP3,直接阻断T细胞分化成Treg。 参考文献:1.IL-21 sIgnaling in Immunity. 2.Tumor Microenvironment:The role of interleukins-Part A. 3.The role of IL-21 in Immunity and Cancer. ...
IL-21R以同源二聚体形式存在，其胞内区可能有STAT5锚定位点，且γ链是IL-21R复合物的必需亚单位，参与IL-21R的信号转导。因此IL-21R可以激活STAT信号通路（下游靶蛋白包括JAK1、JAK2、JAK3、STAT3和STAT5等），促进细胞增殖。当γ链与相应的配体（如IL-21）结合后，引起JAK3的磷酸化，并将信号传导给下游...
[2]孙稳平, 李云岗, 王会波. 白细胞介素21及其研究进展. 动物医学进展. 2007;28:74-77. [3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002...
[3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002,41(27):8725-8731. [4]Jin H, Malek TR. Redundant and unique regulation of activated...
Signaling pathwaysgamma c Cytokine familyJAK-STAT pathwaysIL-21 is an immunomodulatory cytokine produced by natural killer (NK) cells and T cells that has pleiotropic roles in immune and nonimmune cells. IL-21 can modulate innate and specific immunity......
德国莱布尼茨免疫治疗研究所Luca Gattinoni教授和美国国家心肺血液研究所Warren J. Leonard教授研究团队于2024年8月9在Signal Transduction and Targeted Therapy发表题为“LIM-domain-only 4 (LMO4) enhances CD8+T-cell stemness and...
21plays an important role in autoimmune diseases ，inflammatory diseases and cancer.This article mainly reviews the current research status of IL -21signaling pathways and functions ，as well as the research progress of pathogenesis in tumors and hypertension.［Key words ］Cytokine ；IL -21；Immune ...
关键词白细胞介素21;JAK/STAT信号通路;免疫性血小板减少症中图分类号R558.2 文献标识码Adoi:10.7534/j.issn.1009.2137.2018.03.038Changes of IL-21 and Its Mediated JAK/STAT Signaling Pathway inZHANG Qian+,BAI Hai,YU Xiao一胁f,WU Bing,以ⅣYao—Zhu,WANG Cun.Bang,ZHA0 Li.Ping,LI Wen.Bo,XU n...
IL-21是一种新发现的细胞因子,结构上与IL-2、IL-15相似,可调控T细胞、B细胞增殖,影响NK细胞的分化成熟及其胞毒效应,并参与造血系统的发育;其受体IL-21R 与部分细胞因子共用γ链(γc),可能参与性连锁严重联合免疫缺陷(XSCID)的发病.答