参考文献 [1] Leonard, W.J. & Wan, C.K. IL-21 Signaling in Immunity. F1000Res 5 (2016). 百奥动物还在持续开发一系列细胞因子人源化小鼠模型,助力全球新药研发!点击“
IL-21R信号通路通过降低IL-2的表达间接抑制Treg的免疫抑制功能。IL-21可抑制幼稚CD4+T细胞中肿瘤介导的FOXP3,直接阻断T细胞分化成Treg。 参考文献:1.IL-21 sIgnaling in Immunity. 2.Tumor Microenvironment:The role of interleukins-Part A. 3.The role of IL-21 in Immunity and Cancer. ...
Signaling pathwaysgamma c Cytokine familyJAK-STAT pathwaysIL-21 is an immunomodulatory cytokine produced by natural killer (NK) cells and T cells that has pleiotropic roles in immune and nonimmune cells. IL-21 can modulate innate and specific immunity......
are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408:57-63. [2]孙稳平, 李云岗, 王会波. 白细胞介素21及其研究进展. 动物医学进展. 2007;28:74-77.[3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling ...
[3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002,41(27):8725-8731. [4]Jin H, Malek TR. Redundant and unique regulation of activated...
[3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002,41(27):8725-8731. [4]Jin H, Malek TR. Redundant and unique regulation of activated...
21plays an important role in autoimmune diseases ，inflammatory diseases and cancer.This article mainly reviews the current research status of IL -21signaling pathways and functions ，as well as the research progress of pathogenesis in tumors and hypertension.［Key words ］Cytokine ；IL -21；Immune ...
IL-21与IL-21R结合后,可以调节B淋巴细胞的增殖,并有效促进T细胞和NK细胞的增殖及分化,在免疫调节、抗肿瘤等领域发挥着重要的作用。IL-21能结合不同种类的免疫细胞并将它们进行活化,从而发挥多种不同的免疫学效应:直接调节B淋巴细胞的增殖和凋亡,促进免疫球蛋白的产生和同种类型的转换;增强CD8+T细胞、自然杀伤细胞...
[3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002,41(27):8725-8731. [4]Jin H, Malek TR. Redundant and unique regulation of activated...
德国莱布尼茨免疫治疗研究所Luca Gattinoni教授和美国国家心肺血液研究所Warren J. Leonard教授研究团队于2024年8月9在Signal Transduction and Targeted Therapy发表题为“LIM-domain-only 4 (LMO4) enhances CD8+T-cell stemness and...